Nootropic
Phenylethylamine (PEA)
Also known as: PEA, β-Phenylethylamine, Phenylethylamine HCl, 2-phenylethylamine
Phenylethylamine (PEA) is an endogenous trace amine that acts as a neuromodulator, primarily known for mood and focus support. Limited human clinical evidence exists; most data is from animal studies or in vitro research.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Mood
- Focus
- Energy
- Rapid onset
- Mood elevation
- Mental focus and alertness
- Energy support
How it works
- Releases dopamine and norepinephrine
- Trace amine receptor activity
- Very rapid metabolism
Dosage
- Typical range
- 100-500 mg
- Timing
- As needed, short duration
- With food
- Empty stomach
- Duration
- Only lasts 15-30 minutes alone
- Special populations
- Acute mood boost
Forms
- Capsules
- Powder
- HCl powder· 70/100
Safety
Common side effects
- Rapid heart rate
- Anxiety
- Crash
Contraindications
- MAOIs
- Heart conditions
Products containing Phenylethylamine (PEA)
Top-scoring supplements in our catalog that list Phenylethylamine (PEA) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Very short-acting mood boost
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Nootropic
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.