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Adaptogen

Rhodiola

Also known as: Rosavin

A
Evidence

Adaptogen that helps the body adapt to stress, supporting HPA axis and adrenal function.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

Add Thorne Rhodiola to your stack — free
The highest-scored Rhodiola product in our catalog (92/100). Track dose and overlaps in the app.
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Every Rhodiola product we have scored

Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.

Common questions

How much Rhodiola should I take?

The typical range is 200-600mg standardized extract daily. Cycle: 8-12 weeks on, 2-4 weeks off

When should I take Rhodiola?

Morning and early afternoon (stimulating). Either way.

Which form of Rhodiola is best?

Capsule — SHR-5 extract studied. Other forms in the catalog: Standardized extract, Capsules.

Is Rhodiola safe?

Commonly reported: Insomnia if taken late, Jitteriness, Dry mouth. Serious warnings: Stimulating - not for anxiety-predominant presentations, May worsen bipolar. Safe

Which Rhodiola supplement scores highest?

Thorne Rhodiola, at 92/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.

Primary uses

  • Mild depression
  • Fatigue
  • Stress resilience
  • Stress adaptation
  • Adrenal support
  • Mental performance

What systematic reviews concluded

Outcomes that systematic reviews of Rhodiola reached a verdict on: 8 with a benefit, 6 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.

Reviews found a benefit (8)

Benefitstress and anxiety
“reduction of stress and anxiety” PMID 41906501
Benefitdepressive symptoms
“alleviation of depressive symptoms” PMID 41906501 · 2 reviews
Every supplement reviewed for depression →
Benefitsleep quality
“improved sleep quality” PMID 41906501
Benefitmuscle strength and recovery
“increased muscle strength and recovery” PMID 41906501
Every supplement reviewed for muscle strength & mass →
Benefitexercise performance
“Acute supplementation with RR has a positive effect on endurance performance and rating of perceived exertion (RPE).” PMID 37495266 · 2 reviews
Every supplement reviewed for exercise performance →
Benefitangina symptoms
“On the basis of routine treatment, Rhodiola could further improve patients' symptoms.” PMID 25223177

and 2 more.

Not enough to say: cognitive function; exercise-induced muscle damage; hpa axis activity; psychiatric disorder treatment; cognitive performance; physical/sports performance.

How it works

  • Modulates HPA axis
  • Reduces cortisol spikes
  • Supports stress resilience
  • Anti-fatigue effects

Dosage

Typical range
200-600mg standardized extract daily
Timing
Morning and early afternoon (stimulating)
With food
Either way
Duration
Cycle: 8-12 weeks on, 2-4 weeks off
Special populations
Stress-related fatigue, burnout, adrenal support

Forms

  • Capsule
  • Standardized extract
  • Capsules

Safety

Common side effects

  • Insomnia if taken late
  • Jitteriness
  • Dry mouth

Contraindications

  • Bipolar disorder
  • Anxiety (may worsen some)

Products containing Rhodiola

Top-scoring supplements in our catalog that list Rhodiola on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

See all products →

Known interactions

Evidence notes

Strong evidence for stress adaptation and fatigue

Grade A: Multiple well-designed human trials support the main claims.

Cited research for Rhodiola

Clinical studies referenced across Formulate guides that mention rhodiola. Each links to the full study page with PubMed source + the guides that cite it.

Rhodiola compared head-to-head

Related in Adaptogen

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.