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Adaptogen

Eleutherococcus senticosus Extract (Siberian Ginseng)

Also known as: Siberian Ginseng, Eleuthero, Acanthopanax senticosus, Eleutherococcus

B
Evidence

Eleutherococcus senticosus is a traditional adaptogenic herb used to support stress resilience, energy, and physical performance. Evidence is moderate but inconsistent, with most studies showing modest benefits for stamina and fatigue under stress conditions.

Primary uses

  • Stress support and resilience
  • Energy and fatigue reduction
  • Physical performance and endurance
  • Immune function support
  • Mental focus and concentration

How it works

  • Adaptogenic effects via modulation of HPA axis activity
  • Eleutherosides act as bioactive compounds supporting stress response
  • Potential antioxidant and anti-inflammatory effects
  • Modulation of cortisol and catecholamine responses

Dosage

Typical range
300-600 mg daily (standardized to 2% eleutherosides)
Timing
Morning or early afternoon; divided doses if using higher amounts
With food
Can be taken with or without food
Duration
Typically used for 8-12 week periods; some sources suggest 2-3 weeks on, 1-2 weeks off for sustained benefit
Special populations
Generally safe for most adults; consult provider if pregnant, nursing, or on stimulant medications

Forms

  • Root extract powder· 70/100
  • Tablets· 70/100
  • Capsules· 70/100
  • Liquid extract· 70/100
  • Tea· 70/100

Safety

Common side effects

  • Mild insomnia (if taken late in day)
  • Headache (rare)
  • Mild gastrointestinal upset
  • Anxiety or agitation (at higher doses)

Contraindications

  • Stimulant-sensitive individuals should use cautiously
  • May theoretically interfere with immunosuppressive therapy
  • Caution with hormone-sensitive conditions (inconsistent evidence)
  • Not recommended during acute febrile illness

Evidence notes

Moderate evidence from multiple clinical trials showing benefits for stress adaptation, fatigue, and physical performance in athletes and stressed populations. Studies are generally small-to-medium quality with some methodological limitations. The 2% eleutheroside standardization provides consistent marker compound levels but clinical significance varies by endpoint.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.