Adaptogen
Eleutherococcus senticosus Extract (Siberian Ginseng)
Also known as: Siberian Ginseng, Eleuthero, Acanthopanax senticosus, Eleutherococcus
Eleutherococcus senticosus is a traditional adaptogenic herb used to support stress resilience, energy, and physical performance. Evidence is moderate but inconsistent, with most studies showing modest benefits for stamina and fatigue under stress conditions.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Stress support and resilience
- Energy and fatigue reduction
- Physical performance and endurance
- Immune function support
- Mental focus and concentration
How it works
- Adaptogenic effects via modulation of HPA axis activity
- Eleutherosides act as bioactive compounds supporting stress response
- Potential antioxidant and anti-inflammatory effects
- Modulation of cortisol and catecholamine responses
Dosage
- Typical range
- 300-600 mg daily (standardized to 2% eleutherosides)
- Timing
- Morning or early afternoon; divided doses if using higher amounts
- With food
- Can be taken with or without food
- Duration
- Typically used for 8-12 week periods; some sources suggest 2-3 weeks on, 1-2 weeks off for sustained benefit
- Special populations
- Generally safe for most adults; consult provider if pregnant, nursing, or on stimulant medications
Forms
- Root extract powder· 70/100
- Tablets· 70/100
- Capsules· 70/100
- Liquid extract· 70/100
- Tea· 70/100
Safety
Common side effects
- Mild insomnia (if taken late in day)
- Headache (rare)
- Mild gastrointestinal upset
- Anxiety or agitation (at higher doses)
Contraindications
- Stimulant-sensitive individuals should use cautiously
- May theoretically interfere with immunosuppressive therapy
- Caution with hormone-sensitive conditions (inconsistent evidence)
- Not recommended during acute febrile illness
Products containing Eleutherococcus senticosus Extract (Siberian Ginseng)
Top-scoring supplements in our catalog that list Eleutherococcus senticosus Extract (Siberian Ginseng) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Moderate evidence from multiple clinical trials showing benefits for stress adaptation, fatigue, and physical performance in athletes and stressed populations. Studies are generally small-to-medium quality with some methodological limitations. The 2% eleutheroside standardization provides consistent marker compound levels but clinical significance varies by endpoint.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.