Adaptogen

Licorice

Also known as: Glycyrrhiza glabra, Licorice, Licorice Root, Gan cao

Evidence

Root that inhibits cortisol breakdown, extending its effects—useful for low cortisol states.

Primary uses

Adrenal support
Low cortisol
Digestive support
Low cortisol support
Fatigue
Low blood pressure

How it works

Inhibits cortisol breakdown (11β-HSD)
Extends cortisol half-life
Mineralocorticoid effects

Dosage

Typical range: 200-400mg extract (NOT DGL)
Timing: Morning
With food: Either
Duration: Short courses, not long-term
Special populations: Low cortisol, adrenal fatigue (not high cortisol!)

Forms

Whole root
DGL
Whole root extract
Standardized extract
NOT DGL

Safety

Common side effects

Raised blood pressure
Water retention
Headache

Contraindications

Hypertension
Heart disease
Kidney disease
HIGH cortisol

Known interactions

Warningwith blood pressure medications
Licorice raises blood pressure, opposing medication

Evidence notes

Extends cortisol action (use for LOW cortisol only)

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.