Adaptogen

Licorice

Also known as: Glycyrrhiza glabra, Licorice, Licorice Root, Gan cao

Evidence

Root that inhibits cortisol breakdown, extending its effects—useful for low cortisol states.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Adrenal support
Low cortisol
Digestive support
Low cortisol support
Fatigue
Low blood pressure

How it works

Inhibits cortisol breakdown (11β-HSD)
Extends cortisol half-life
Mineralocorticoid effects

Dosage

Typical range: 200-400mg extract (NOT DGL)
Timing: Morning
With food: Either
Duration: Short courses, not long-term
Special populations: Low cortisol, adrenal fatigue (not high cortisol!)

Forms

Whole root
DGL
Whole root extract
Standardized extract
NOT DGL

Safety

Common side effects

Raised blood pressure
Water retention
Headache

Contraindications

Hypertension
Heart disease
Kidney disease
HIGH cortisol

Products containing Licorice

Top-scoring supplements in our catalog that list Licorice on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Known interactions

Warningwith blood pressure medications
Licorice raises blood pressure, opposing medication

Evidence notes

Extends cortisol action (use for LOW cortisol only)

Grade B: Some human trials support key claims; further confirmation needed.

Related in Adaptogen

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.