Amino Acid

L-Glutamine (Gut Repair)

Also known as: Glutamine, L-glutamine

Evidence

Primary fuel for intestinal cells, essential for gut barrier repair and reducing intestinal permeability.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

5 g / day

L-Glutamine (Gut Repair) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

Gut barrier repair
Leaky gut
IBD support
Enterocyte fuel

How it works

Primary fuel for enterocytes
Supports tight junction integrity
Reduces intestinal permeability
Aids mucosal healing

Dosage

Typical range: 5-20g daily for gut healing, 2-5g maintenance
Timing: Away from protein meals or divided throughout day
With food: Either way
Duration: High dose 2-3 months for healing, then maintenance
Special populations: Leaky gut, IBD, post-antibiotic, athletes

Forms

Powder
Capsules

Safety

Common side effects

Rare at normal doses

Contraindications

Hepatic encephalopathy
Severe liver disease

Products containing L-Glutamine (Gut Repair)

Top-scoring supplements in our catalog that list L-Glutamine (Gut Repair) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Post Workout Supplement

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Evidence notes

Strong evidence for gut barrier support

Grade A: Multiple well-designed human trials support the main claims.

Cited research for L-Glutamine (Gut Repair)

Clinical studies referenced across Formulate guides that mention l-glutamine (gut repair). Each links to the full study page with PubMed source + the guides that cite it.

Shao A, Hathcock JN (2008)Regulatory Toxicology and Pharmacology
Risk assessment for the amino acids taurine, L-glutamine and L-arginine

Related in Amino Acid

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.