Sleep
Honokiol
Also known as: Magnolia bark extract (isolated)
Isolated magnolia bark compound with potent GABA-A effects. More specific than whole bark.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Anxiety relief
- Sleep support
- Neuroprotection
How it works
- Potent GABA-A positive modulator
- Brain antioxidant
- Anti-inflammatory
Dosage
- Typical range
- 50-200mg
- Timing
- Evening or as needed
- With food
- Either
- Duration
- Safe for regular use
- Special populations
- Anxiety, sleep
Forms
- Capsule
Safety
Common side effects
- Drowsiness
- Mild sedation
Contraindications
- Pregnancy
Evidence notes
Active compound from magnolia bark
Grade B: Some human trials support key claims; further confirmation needed.
Related in Sleep
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Honokiol fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.