Sleep
Apigenin
Also known as: 4',5,7-trihydroxyflavone, Chamomile extract, Chamomile flavonoid
B
Evidence
Chamomile flavonoid with mild sedative and anti-anxiety effects. Binds GABA receptors.
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Primary uses
- Sleep
- Anxiety
- Relaxation
How it works
- GABA-A receptor modulation
- CD38 inhibition (NAD+ sparing)
- Anti-inflammatory
Dosage
- Typical range
- 50-300 mg before bed
- Timing
- Evening
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Sleep, mild anxiety
Forms
- Capsules
- Chamomile tea/extract
Safety
Common side effects
- Drowsiness
- Allergic reaction if chamomile-sensitive
Contraindications
- Chamomile/ragweed allergy
Products containing Apigenin
Top-scoring supplements in our catalog that list Apigenin on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Chamomile's active compound
Grade B: Some human trials support key claims; further confirmation needed.
Related in Sleep
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