Sleep

Apigenin

Also known as: 4',5,7-trihydroxyflavone, Chamomile extract, Chamomile flavonoid

Evidence

Chamomile flavonoid with mild sedative and anti-anxiety effects. Binds GABA receptors.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Sleep
Anxiety
Relaxation

How it works

GABA-A receptor modulation
CD38 inhibition (NAD+ sparing)
Anti-inflammatory

Dosage

Typical range: 50-300 mg before bed
Timing: Evening
With food: Optional
Duration: Safe long-term
Special populations: Sleep, mild anxiety

Forms

Capsules
Chamomile tea/extract

Safety

Common side effects

Drowsiness
Allergic reaction if chamomile-sensitive

Contraindications

Chamomile/ragweed allergy

Products containing Apigenin

Top-scoring supplements in our catalog that list Apigenin on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Chamomile's active compound

Grade B: Some human trials support key claims; further confirmation needed.

Related in Sleep

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.