Sleep

Apigenin

Also known as: 4',5,7-trihydroxyflavone, Chamomile extract, Chamomile flavonoid

Evidence

Chamomile flavonoid with mild sedative and anti-anxiety effects. Binds GABA receptors.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

Add Momentous Apigenin Supplement to your stack — free

The highest-scored Apigenin product in our catalog (90/100). Track dose and overlaps in the app.

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Every Apigenin product we have scored

#	Product	Score	Per serving
1	Momentous Apigenin Supplement	90 A	$0.38
2	Thorne Deep Sleep Complex	86 A-	$1.73
3	Complement Restore	86 A-	$1.90
4	Pure Encapsulations Daily Stress Formula	86 A-	$1.38
5	Pure Encapsulations Best-Rest Formula	84 A-	$1.23
6	Garden of Life mykind Organics Sleep Well Rest & Refresh	83 A-	$0.77
7	Nested Naturals LUNA Gentle Sleep Supplement	82 A-	$0.73
8	Pure Encapsulations Muscle Cramp/Tension Formula	81 A-	$0.65
9	Olly Ultra Strength Sleep Softgels	81 A-	$0.67
10	Life Extension One-Per-Day Tablets	81 A-	$0.35
11	Life Extension Two-Per-Day Multivitamin	80 A-	$0.34
12	Terra Origin Healthy Sleep & Wake	78 B+	$0.42

Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.

Common questions

How much Apigenin should I take?

The typical range is 50-300 mg before bed. Safe long-term

When should I take Apigenin?

Evening. Optional.

Which form of Apigenin is best?

Capsules — Isolated compound. Other forms in the catalog: Chamomile tea/extract.

Is Apigenin safe?

Commonly reported: Drowsiness, Allergic reaction if chamomile-sensitive. Serious warnings: Ragweed allergy cross-reaction. Safe

Which Apigenin supplement scores highest?

Momentous Apigenin Supplement, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.

Primary uses

Sleep
Anxiety
Relaxation

How it works

GABA-A receptor modulation
CD38 inhibition (NAD+ sparing)
Anti-inflammatory

Dosage

Typical range: 50-300 mg before bed
Timing: Evening
With food: Optional
Duration: Safe long-term
Special populations: Sleep, mild anxiety

Forms

Capsules
Chamomile tea/extract

Safety

Common side effects

Drowsiness
Allergic reaction if chamomile-sensitive

Contraindications

Chamomile/ragweed allergy

Products containing Apigenin

Top-scoring supplements in our catalog that list Apigenin on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Momentous

Thorne

Complement

Pure Encapsulations

Evidence notes

Chamomile's active compound

Grade B: Some human trials support key claims; further confirmation needed.

Related in Sleep

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.