Herbal Extract
Graviola Extract (Annona muricata)
Also known as: Soursop extract, Annona muricata leaf extract, Graviola leaf, Soursop leaf
Graviola is a tropical fruit tree extract traditionally used in folk medicine, primarily studied for potential cytotoxic effects on cancer cell lines in vitro. Human clinical evidence remains extremely limited, with most research conducted in laboratory settings rather than human trials.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Traditional immune support
- Antioxidant support
- General wellness
How it works
- Contains acetogenins (annonaceous compounds) with in vitro cytotoxic activity
- Antioxidant activity from phenolic compounds
- Traditional use suggests anti-inflammatory properties
Dosage
- Typical range
- 800-4,000 mg daily (equivalent extract weight)
- Timing
- Typically divided doses with meals
- With food
- Recommended with food to minimize potential gastrointestinal effects
- Duration
- Long-term safety data in humans is lacking; extended use should be discussed with healthcare provider
- Special populations
- Not studied in pregnancy, lactation, or pediatric populations; avoid if immunocompromised or undergoing cancer treatment without medical supervision
Forms
- Extract powder (20:1 concentration)· 70/100
- Leaf powder· 70/100
- Tea/decoction· 70/100
Safety
Common side effects
- Nausea
- Gastrointestinal upset
- Mild diarrhea
- Headache (rare)
Contraindications
- Pregnancy and lactation (insufficient safety data)
- Concurrent chemotherapy or immunosuppressive therapy (potential interactions)
- Parkinson's disease (preliminary data suggests neurotoxic compounds in related species)
- Known hypersensitivity to Annonaceae family plants
Evidence notes
Evidence is predominantly limited to in vitro and animal studies. No robust human randomized controlled trials support efficacy for any health claim. Traditional use in tropical medicine is documented but lacks scientific validation in humans.
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.