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Herbal Extract

Black Walnut Hulls Extract

Also known as: Black Walnut Hull, Juglans nigra hull, Walnut hull extract

C
Evidence

Black walnut hulls are traditionally used in herbal medicine and contain juglone and polyphenols with antimicrobial and antioxidant properties. Limited clinical evidence supports most health claims, with most research conducted in vitro or in animal models.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Digestive support
  • Antimicrobial support
  • Antioxidant support
  • Traditional parasite cleanse

How it works

  • Juglone compound exhibits antimicrobial activity against bacteria and fungi
  • Polyphenol content may provide antioxidant effects
  • Traditional use as antiparasitic agent

Dosage

Typical range
200-500 mg daily (dried extract) or 1-2 ml tincture daily
Timing
With meals
With food
Recommended to take with food to minimize GI upset
Duration
Traditional use suggests 2-4 week cycles; avoid prolonged continuous use without medical supervision
Special populations
Avoid during pregnancy and lactation; use cautiously in children; consult healthcare provider if taking medications

Forms

  • Liquid extract· 70/100
  • Tincture· 70/100
  • Powder· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Nausea
  • Digestive upset
  • Staining of teeth or tongue (dark discoloration)
  • Allergic reactions in sensitized individuals

Contraindications

  • Pregnancy and breastfeeding
  • Hypersensitivity to Juglans species
  • Severe GI conditions
  • Concurrent use with iron supplements or iron-dependent medications (juglone may inhibit iron absorption)

Evidence notes

Most evidence is from traditional use and in vitro studies. Limited human clinical trials; mechanisms plausible but not well-validated in humans. Safety profile unclear with heavy use.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.