Herbal Extract

Baikal Skullcap

Also known as: Scutellaria baicalensis, Chinese skullcap, baicalensis root, scute

Evidence

Baikal skullcap is a traditional Chinese medicinal herb containing bioactive flavonoids (baicalin, wogonin) with preliminary evidence for anxiolytic, anti-inflammatory, and neuroprotective properties. Most human research remains limited, with effects primarily demonstrated in animal models and in vitro studies.

Primary uses

Anxiety and stress support
Sleep quality
Inflammation management
Neuroprotection
Inflammation support
Antioxidant support
Traditional immune support
Stress and relaxation

How it works

Flavonoid compounds (baicalin, baicalein, wogonin) exhibit antioxidant activity
May modulate inflammatory pathways and cytokine production
Potential GABA receptor interaction (preliminary evidence)

Dosage

Typical range: 500-2000 mg daily (dried root powder) or 300-600 mg standardized extract
Timing: Can be taken with meals; traditionally consumed as decoction 2-3 times daily
With food: No specific requirement; may take with or without food
Duration: Traditional use supports long-term consumption; optimal duration for specific benefits not established in human studies
Special populations: Pregnancy/nursing: limited safety data; use with caution. Pediatric: insufficient evidence.

Forms

Extract powder· 70/100
Tablet· 70/100
Capsule· 70/100
Standardized extract· 70/100
Powder· 70/100
Capsules· 70/100
Extract· 70/100
Decoction· 70/100

Safety

Common side effects

Generally well-tolerated in traditional use
Rare: gastrointestinal upset
Rare: allergic reactions (uncommon)

Contraindications

Pregnancy and nursing (insufficient safety data)
Severe liver disease (use with caution)
Known hypersensitivity to Scutellaria species

Evidence notes

Substantial in vitro and animal model data supports anti-inflammatory and antioxidant effects; human clinical trials are sparse and often low-quality. Traditional use is well-documented, but modern RCT evidence in humans is limited. Grade reflects moderate/preliminary human evidence.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.