Herbal Extract
Perilla Extract (Perilla frutescens)
Also known as: Perilla frutescens aerial parts, Shiso extract, Perilla leaf extract, Perilla powder
Perilla frutescens is a traditional Asian herb containing rosmarinic acid and other polyphenols with potential anti-inflammatory and antioxidant properties. Limited human clinical evidence exists; most research is preliminary or conducted in animal models.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Perilla Extract (Perilla frutescens) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations Epi-Integrity powder | 85 A- | $2.00 |
| 2 | Pure Encapsulations Th2 Modulator | 84 A- | $1.02 |
| 3 | Pure Encapsulations Perilla extract | 66 B- | $0.64 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Perilla Extract (Perilla frutescens) should I take?
The typical range is 500–2,000 mg daily (extract powder basis). Most human studies used perilla for 8–12 weeks; longer-term safety data limited
When should I take Perilla Extract (Perilla frutescens)?
With meals for optimal absorption and tolerability. Recommended to reduce potential GI upset.
Which form of Perilla Extract (Perilla frutescens) is best?
Powder. Other forms in the catalog: Extract, Capsule, Leaf (dried).
Is Perilla Extract (Perilla frutescens) safe?
Commonly reported: Gastrointestinal upset (nausea, diarrhea) at higher doses, Allergic reactions (rare, in sensitized individuals).
Which Perilla Extract (Perilla frutescens) supplement scores highest?
Pure Encapsulations Epi-Integrity powder, at 85/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Anti-inflammatory support
- Antioxidant activity
- Respiratory health
- Allergy symptom management
How it works
- Rosmarinic acid-mediated inhibition of inflammatory pathways
- Antioxidant radical scavenging
- Potential modulation of allergic response and mast cell activation
Dosage
- Typical range
- 500–2,000 mg daily (extract powder basis)
- Timing
- With meals for optimal absorption and tolerability
- With food
- Recommended to reduce potential GI upset
- Duration
- Most human studies used perilla for 8–12 weeks; longer-term safety data limited
- Special populations
- Avoid in pregnancy/lactation without professional guidance; limited safety data in children
Forms
- Powder· 70/100
- Extract· 70/100
- Capsule· 70/100
- Leaf (dried)· 70/100
Safety
Common side effects
- Gastrointestinal upset (nausea, diarrhea) at higher doses
- Allergic reactions (rare, in sensitized individuals)
Contraindications
- Known allergy to Perilla frutescens or Lamiaceae family plants
- Pregnancy and lactation (insufficient safety data)
- Bleeding disorders (theoretical risk due to anticoagulant properties in some studies)
Products containing Perilla Extract (Perilla frutescens)
Top-scoring supplements in our catalog that list Perilla Extract (Perilla frutescens) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Most evidence is from in vitro and animal studies. A few small human trials suggest potential benefit for allergic rhinitis and respiratory symptoms, but sample sizes are limited and methodology variability is high. Insufficient robust RCT data for higher grading.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Herbal Extract
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.