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Herbal Extract

Butterbur Extract (Petasites japonicus)

Also known as: Petasites japonicus, Japanese butterbur, Fuki, Petasin extract

C
Evidence

Butterbur extract is a plant-derived supplement traditionally used for allergy and respiratory support, with petasins as the proposed active compounds. Clinical evidence for seasonal allergy relief is moderate, though long-term safety and efficacy data remain limited.

Primary uses

  • Seasonal allergy symptom relief
  • Respiratory health
  • Inflammation support
  • Migraine prevention

How it works

  • Inhibition of leukotriene and histamine release
  • Anti-inflammatory activity via petasin and isopetasin compounds
  • Potential smooth muscle relaxation in airways

Dosage

Typical range
50-150 mg daily (standardized extract) or as directed on label
Timing
With meals or as directed
With food
May be taken with or without food; food may reduce GI upset
Duration
Typically used seasonally for allergy support; 2-4 weeks may be needed for full benefit
Special populations
Avoid in pregnancy and lactation; limited safety data in children

Forms

  • Capsule (as listed: 4:1 extract concentrate)· 70/100
  • Tablet· 70/100
  • Standardized extract· 70/100

Safety

Common side effects

  • Gastrointestinal upset
  • Headache
  • Allergic reactions (rare, in sensitive individuals)
  • Belching/bloating

Contraindications

  • Pregnancy and lactation
  • Hepatic disease (hepatotoxicity risk with certain preparations)
  • Ragweed/daisy/chrysanthemum allergy (cross-reactivity possible)
  • Birch pollen allergy

Evidence notes

Moderate evidence exists for butterbur in seasonal allergies from several small RCTs, though study quality is mixed and sample sizes limited. Evidence for other uses (migraines, respiratory) is more preliminary. Long-term safety data sparse, particularly regarding hepatotoxicity concerns with some plant preparations.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.