Skip to main content

Herbal Extract

Mullein Leaf Extract

Also known as: Verbascum thapsus, Mullein Leaf, Verbascum

C
Evidence

Mullein leaf has been used traditionally in herbal medicine for respiratory support, but clinical evidence in humans remains limited and primarily consists of traditional use reports rather than robust controlled trials. Most research focuses on in vitro activity and animal models.

Primary uses

  • Respiratory support
  • Cough relief
  • Throat soothing
  • Mucus clearance

How it works

  • Potential demulcent properties (mucilage content)
  • Possible anti-inflammatory effects (saponins)
  • Traditional expectorant activity

Dosage

Typical range
500-1500 mg daily
Timing
Can be taken with meals or between meals; often used as needed for respiratory symptoms
With food
No specific requirement; may be taken with or without food
Duration
Traditional use suggests short-term support during seasonal challenges or acute symptoms; long-term safety in humans not extensively studied
Special populations
Avoid during pregnancy and lactation due to limited safety data

Forms

  • Powder· 70/100
  • Extract· 70/100
  • Tea· 70/100
  • Tincture· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Rare: mild gastrointestinal upset
  • Rare: skin irritation with topical application

Contraindications

  • Pregnancy and lactation
  • Allergy to Scrophulariaceae family plants
  • Individuals with glycemic control concerns (contains small amounts of saponins)

Evidence notes

Limited human clinical trial data. Traditional use is well-documented in herbal medicine systems, but controlled RCTs in humans are scarce. Some in vitro and animal studies suggest potential respiratory benefits, but quality and quantity of evidence do not support A or B grading.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Herbal Extract

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.