Herbal Extract

Mullein Leaf Extract

Also known as: Verbascum thapsus, Mullein Leaf, Verbascum

Evidence

Mullein leaf has been used traditionally in herbal medicine for respiratory support, but clinical evidence in humans remains limited and primarily consists of traditional use reports rather than robust controlled trials. Most research focuses on in vitro activity and animal models.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Respiratory support
Cough relief
Throat soothing
Mucus clearance

How it works

Potential demulcent properties (mucilage content)
Possible anti-inflammatory effects (saponins)
Traditional expectorant activity

Dosage

Typical range: 500-1500 mg daily
Timing: Can be taken with meals or between meals; often used as needed for respiratory symptoms
With food: No specific requirement; may be taken with or without food
Duration: Traditional use suggests short-term support during seasonal challenges or acute symptoms; long-term safety in humans not extensively studied
Special populations: Avoid during pregnancy and lactation due to limited safety data

Forms

Powder· 70/100
Extract· 70/100
Tea· 70/100
Tincture· 70/100
Capsule· 70/100

Safety

Common side effects

Generally well-tolerated
Rare: mild gastrointestinal upset
Rare: skin irritation with topical application

Contraindications

Pregnancy and lactation
Allergy to Scrophulariaceae family plants
Individuals with glycemic control concerns (contains small amounts of saponins)

Evidence notes

Limited human clinical trial data. Traditional use is well-documented in herbal medicine systems, but controlled RCTs in humans are scarce. Some in vitro and animal studies suggest potential respiratory benefits, but quality and quantity of evidence do not support A or B grading.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.