Herbal Extract
Cascara Sagrada Extract 10:1
Also known as: Rhamnus purshiana, Cascara sagrada bark, Sacred bark, Chittem bark
Cascara sagrada is a traditional herbal laxative derived from the bark of Rhamnus purshiana, historically used to promote bowel regularity and relieve occasional constipation. Modern evidence supports its cathartic properties, though long-term use carries safety concerns and it is regulated as an over-the-counter drug in many jurisdictions.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Common questions
How much Cascara Sagrada Extract 10:1 should I take?
The typical range is 300-900 mg daily (cascara sagrada equivalent based on 10:1 extract ratio). Intended for short-term, occasional use only; not recommended for continuous use beyond 1-2 weeks without medical supervision
When should I take Cascara Sagrada Extract 10:1?
Evening or before bedtime for overnight effect. Can be taken with or without food; effects typically occur 6-12 hours after ingestion.
Which form of Cascara Sagrada Extract 10:1 is best?
Extract powder (10:1 concentration). Other forms in the catalog: Dried bark, Capsules.
Is Cascara Sagrada Extract 10:1 safe?
Commonly reported: Abdominal cramping, Diarrhea, Electrolyte imbalance (with prolonged use), Dehydration, Dependency with chronic use.
Which Cascara Sagrada Extract 10:1 supplement scores highest?
BulkSupplements Cascara Sagrada Extract Powder, at 85/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Occasional constipation relief
- Bowel regularity support
- Digestive stimulation
How it works
- Anthraquinone glycosides stimulate colonic muscle contractions
- Increases fluid secretion in the colon
- Promotes peristalsis
Dosage
- Typical range
- 300-900 mg daily (cascara sagrada equivalent based on 10:1 extract ratio)
- Timing
- Evening or before bedtime for overnight effect
- With food
- Can be taken with or without food; effects typically occur 6-12 hours after ingestion
- Duration
- Intended for short-term, occasional use only; not recommended for continuous use beyond 1-2 weeks without medical supervision
- Special populations
- Avoid during pregnancy, lactation, and in children under 12 years; not suitable for individuals with bowel obstruction, inflammatory bowel disease, or acute abdominal pain
Forms
- Extract powder (10:1 concentration)· 70/100
- Dried bark· 70/100
- Capsules· 70/100
Safety
Common side effects
- Abdominal cramping
- Diarrhea
- Electrolyte imbalance (with prolonged use)
- Dehydration
- Dependency with chronic use
Contraindications
- Pregnancy and lactation
- Inflammatory bowel disease (Crohn's, ulcerative colitis)
- Bowel obstruction or impaction
- Appendicitis or undiagnosed abdominal pain
- Severe dehydration
- Chronic use increases risk of laxative dependency and potassium depletion
Products containing Cascara Sagrada Extract 10:1
Top-scoring supplements in our catalog that list Cascara Sagrada Extract 10:1 on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Cascara sagrada has long historical use and established pharmacological activity as a stimulant laxative. Evidence is solid for short-term constipation relief, but B rather than A due to limited modern RCTs and significant safety concerns limiting research. FDA recognized it as an active laxative ingredient, though it has faced regulatory restrictions.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.