Herbal Extract
Supercritical CO2 Ginger Extract (Zingiber officinale)
Also known as: ginger root extract, zingiber officinale supercritical extract, ginger CO2 extract, standardized ginger extract
Supercritical CO2 ginger extract is a concentrated form of ginger root standardized to gingerols and shogaols, the primary bioactive compounds responsible for ginger's anti-inflammatory and digestive properties. Extensive research supports ginger's efficacy for nausea, digestive discomfort, and inflammatory responses.
Primary uses
- Nausea and motion sickness
- Digestive support
- Anti-inflammatory effects
- Joint comfort
- Gastrointestinal health
How it works
- Gingerols and shogaols inhibit inflammatory mediators (TNF-α, IL-6, NF-κB pathway)
- 5-HT antagonism and antiemetic effects via vagal afferent signaling
- Promotes gastric motility and digestive enzyme activity
- Antioxidant activity from polyphenolic compounds
Dosage
- Typical range
- 1–2 grams daily (extract equivalent; adjust based on gingerol content standardization)
- Timing
- With meals for digestive support; 30–60 minutes before travel for nausea
- With food
- Recommended with food to minimize potential gastric irritation
- Duration
- Safe for long-term use; many studies show efficacy with 4–12 weeks of consistent supplementation
- Special populations
- Pregnancy: evidence supports 1–2g daily for morning sickness under medical guidance; avoid in those with bleeding disorders or on anticoagulants without medical supervision
Forms
- Capsule· 70/100
- Powder· 70/100
- Extract· 70/100
Safety
Common side effects
- Mild gastrointestinal upset at higher doses
- Heartburn or acid reflux (occasional)
- Mouth irritation with powdered forms
Contraindications
- Bleeding disorders or concurrent anticoagulant/antiplatelet therapy (minor blood-thinning effects)
- Gallstones (may increase bile flow)
- Acute ulcers or severe GERD (case-dependent; consult physician)
Evidence notes
Ginger has strong clinical evidence for nausea (pregnancy-related, post-operative, motion sickness) and moderate evidence for inflammatory and digestive support. Supercritical CO2 extraction concentrates gingerols/shogaols, but evidence base remains consistent with standardized ginger research; grade reflects well-established efficacy without novel mechanism claims.
Grade B: Some human trials support key claims; further confirmation needed.
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