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Herbal Extract

Andrographis paniculata Extract (10% Andrographolides)

Also known as: Andrographis 10% standardized, Andrographolide-standardized andrographis, Andrographis aerial parts 10% andrographolides, King of Bitters 10% extract

B
Evidence

Andrographis extract standardized to contain 10% andrographolides, the primary active diterpenoid compounds responsible for immune and anti-inflammatory effects. This standardization provides consistent potency across batches.

Primary uses

  • Immune support and enhancement
  • Cold and flu duration/severity reduction
  • Respiratory tract health
  • General anti-inflammatory effects
  • Recovery from infection

How it works

  • Andrographolide-mediated NF-κB pathway inhibition
  • Cytokine modulation (IL-6, TNF-α, IL-10 regulation)
  • T-cell and NK cell activation
  • Interferon production enhancement
  • Antimicrobial and antiviral activity

Dosage

Typical range
200-400 mg daily (10% andrographolide extract)
Timing
With meals; best taken 2-3x daily in divided doses
With food
Recommended to reduce GI irritation and improve absorption
Duration
Evidence supports use for 4-12 weeks; traditional use suggests cycling (4-8 weeks on, 1-2 weeks off)
Special populations
Contraindicated in pregnancy and nursing. Caution in autoimmune conditions. Hepatic disease requires medical supervision.

Forms

  • Capsule· 70/100
  • Tablet· 70/100
  • Powder· 70/100
  • Tincture· 70/100

Safety

Common side effects

  • GI upset (nausea, diarrhea, abdominal pain)
  • Loss of appetite
  • Mild headache
  • Bitter taste

Contraindications

  • Pregnancy and lactation
  • Active autoimmune disease (lupus, rheumatoid arthritis, etc.)
  • Immunosuppressant therapy
  • Gallbladder dysfunction or obstruction
  • Recent transplant surgery

Evidence notes

Strong clinical evidence for andrographolide-standardized extracts (typically 3-10% andrographolides) in reducing cold/flu duration and symptoms. Multiple RCTs support immune efficacy. Standardization to andrographolides (the primary active marker) provides more reliable clinical outcomes than concentration ratios alone.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.