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Herbal Extract

Andrographis Paniculata

Also known as: Andrographis extract 10:1, Concentrated andrographis, King of Bitters extract, Andrographis paniculata Extract

B
Evidence

An extract derived specifically from the leaves of Andrographis paniculata, which contain the highest concentration of andrographolide compounds. Leaf extracts are considered the most potent source of andrographis' active constituents.

Primary uses

  • Immune support
  • Cold and flu symptom duration reduction
  • Upper respiratory tract health
  • General anti-inflammatory support
  • Immune system support
  • Cold and flu symptom relief
  • Upper respiratory health
  • Anti-inflammatory effects
  • General wellness and immune maintenance

How it works

  • Modulation of inflammatory cytokines (IL-6, TNF-α)
  • Enhanced immune cell activation and proliferation
  • Potential NF-κB pathway inhibition
  • Antimicrobial and antiviral properties

Dosage

Typical range
300-600 mg daily (10:1 extract)
Timing
With meals for better absorption and to minimize GI upset
With food
Recommended; andrographis may cause mild GI distress on empty stomach
Duration
Safe for 3-12 weeks of continuous use; some recommend 4-week cycles with 1-2 week breaks
Special populations
Pregnancy contraindicated (traditional abortifacient use); nursing mothers should avoid. Use caution in autoimmune conditions.

Forms

  • Capsule· 70/100
  • Powder· 70/100
  • Tablet· 70/100
  • Liquid extract· 70/100
  • Tea/infusion· 70/100

Safety

Common side effects

  • Mild GI upset (nausea, diarrhea, abdominal discomfort)
  • Loss of appetite
  • Headache (rare)
  • Allergic reactions (rare, in sensitive individuals)

Contraindications

  • Pregnancy and nursing
  • Autoimmune diseases (may overstimulate immune function)
  • Immunosuppressant therapy
  • Bile duct obstruction or gallbladder disease

Evidence notes

Multiple clinical trials demonstrate efficacy for reducing cold symptom duration and severity; good evidence for immune support, though most studies used crude extract or standardized andrographolide forms. The 10:1 ratio itself lacks specific pharmacokinetic data.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.