Digestive
Betaine HCl
Also known as: Betaine HCL, Betaine hydrochloride, HCL, HCl
Supplemental stomach acid for those with low acid production. Supports protein digestion and mineral absorption.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Low stomach acid
- Protein digestion
- Mineral absorption
- GERD (low-acid type)
How it works
- Provides supplemental HCl
- Activates pepsin
- Improves mineral absorption
Dosage
- Typical range
- 325-650 mg per protein meal
- Timing
- Middle of protein-containing meal
- With food
- Yes, protein meals
- Duration
- Find effective dose
- Special populations
- Over 50, PPI users
Forms
- Capsules with pepsin
Safety
Common side effects
- Warmth in stomach
Contraindications
- Active ulcer
- Gastritis
- NSAIDs
Products containing Betaine HCl
Top-scoring supplements in our catalog that list Betaine HCl on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Addresses hypochlorhydria
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.