Advanced Digestive Enzymes
Scored by the Formulate Research Team · Last reviewed July 2026
Overview: Thorne Advanced Digestive Enzymes
A digestive enzyme blend that supports individuals who have indigestion or bloating* Advanced Digestive Enzymes promotes the digestion and absorption of proteins, fats, and carbs with the combination of HCl, pepsin, pancreatic enzymes, and ox bile.*
Score Breakdown
Formulate scores every product across six weighted dimensions. Each dimension is graded independently — hover or tap to see what drove each component.
Ingredients per Serving
| Ingredient | Amount |
|---|---|
| Betaine Hydrochloride2 randomised trials | 1440 mg |
| Pepsin24 randomised trials | 210 mg |
| L-Glutamic Acid Hydrochloride4 systematic reviews · 72 randomised trials | 1440 mg |
| Ox Bile1 human trial | 240 mg |
| Pancreatin1 systematic review · 15 randomised trials | 420 mg |
Certifications & Testing
Other Ingredients
Calcium Laurate, Hypromellose (derived from cellulose) capsule, Leucine
Recommended Use
Take 1-2 capsules with each meal.
Warnings
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY If pregnant, consult your health-care practitioner before using this product. INTERACTIONS Advanced Digestive Enzymes should not be used concurrent with H2-blocking drugs and proton pump inhibitors because these drugs are intended to block the production of stoma
Frequently Asked Questions
What is Thorne Advanced Digestive Enzymes's Formulate score?
Thorne Advanced Digestive Enzymes scores 84 out of 100 (grade A-) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.
Is Thorne Advanced Digestive Enzymes worth it?
Thorne Advanced Digestive Enzymes scores 84/100 (grade A-). That puts it in Formulate's top tier: its ingredient doses, forms, and label transparency hold up against the clinical evidence, and it carries credible third-party testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.
What's in Thorne Advanced Digestive Enzymes?
Each serving contains Betaine Hydrochloride (1440 mg), Pepsin (210 mg), L-Glutamic Acid Hydrochloride (1440 mg), Ox Bile (240 mg), and more. Serving size: 2 Capsules. 90 servings per container.
How do I take advanced digestive enzymes?
Take 1-2 capsules with each meal.
Who makes Advanced Digestive Enzymes?
Advanced Digestive Enzymes is made by Thorne. See Formulate's full grade and product lineup for Thorne on its brand page.
Is Thorne Advanced Digestive Enzymes third-party tested?
Thorne lists the following certifications and testing for this product: NSF Certified, Gluten Free, Dairy Free, Soy Free, Thorne Verified, Natural Flavors, Natural Colors, GMP Certified.
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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.