Skip to main content

Digestive Enzyme

Pepsin

Also known as: Pepsin, Pepsin (Porcine), Porcine Pepsin, Pepsin A

B
Evidence

Digestive enzyme derived from porcine stomach lining that breaks down proteins in acidic environments. Works synergistically with hydrochloric acid for protein digestion.

Primary uses

  • Protein digestion support
  • Digestive enzyme supplementation
  • Hypochlorhydria support

How it works

  • Cleaves peptide bonds in proteins
  • Works optimally in acidic pH (1.5-2.5)
  • Activated by hydrochloric acid

Dosage

Typical range
20-250 mg with meals
Timing
With protein-containing meals
With food
Yes - take at start of meal
Duration
As needed with meals
Special populations
Often combined with Betaine HCl

Forms

  • Porcine-derived
  • 1:10,000 or 1:3000

Safety

Common side effects

  • Rare at normal doses

Contraindications

  • Active peptic ulcer
  • Gastritis
  • Pork allergy

Evidence notes

Well-established digestive enzyme; moderate evidence for protein digestion support

Grade B: Some human trials support key claims; further confirmation needed.

Related in Digestive Enzyme

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.