Digestive Enzyme
Pepsin
Also known as: Pepsin, Pepsin (Porcine), Porcine Pepsin, Pepsin A
Digestive enzyme derived from porcine stomach lining that breaks down proteins in acidic environments. Works synergistically with hydrochloric acid for protein digestion.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Protein digestion support
- Digestive enzyme supplementation
- Hypochlorhydria support
How it works
- Cleaves peptide bonds in proteins
- Works optimally in acidic pH (1.5-2.5)
- Activated by hydrochloric acid
Dosage
- Typical range
- 20-250 mg with meals
- Timing
- With protein-containing meals
- With food
- Yes - take at start of meal
- Duration
- As needed with meals
- Special populations
- Often combined with Betaine HCl
Forms
- Porcine-derived
- 1:10,000 or 1:3000
Safety
Common side effects
- Rare at normal doses
Contraindications
- Active peptic ulcer
- Gastritis
- Pork allergy
Products containing Pepsin
Top-scoring supplements in our catalog that list Pepsin on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Well-established digestive enzyme; moderate evidence for protein digestion support
Grade B: Some human trials support key claims; further confirmation needed.
Related in Digestive Enzyme
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.