Digestive Enzyme
Pancreatin
Also known as: Pancreatin, Pancreatic enzymes, Porcine pancreatin, Pancrelipase
B
Evidence
Digestive enzyme complex derived from porcine pancreas containing amylase, lipase, and protease. Supports digestion of proteins, fats, and carbohydrates.
Primary uses
- Digestive support
- Pancreatic insufficiency
- Malabsorption
How it works
- Breaks down proteins (protease)
- Breaks down fats (lipase)
- Breaks down carbohydrates (amylase)
Dosage
- Typical range
- 500-2000 mg with meals (or by USP units)
- Timing
- With meals
- With food
- Yes - take at start of meal
- Duration
- As needed with meals
- Special populations
- Higher doses for pancreatic insufficiency
Forms
- Porcine-derived
- Enteric-coated
- USP units
Safety
Common side effects
- Nausea
- Abdominal discomfort
- Diarrhea at high doses
Contraindications
- Acute pancreatitis
- Pork allergy
Evidence notes
Well-established for pancreatic insufficiency; moderate evidence for general digestive support
Grade B: Some human trials support key claims; further confirmation needed.
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