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Digestive Enzyme

Pancreatin

Also known as: Pancreatin, Pancreatic enzymes, Porcine pancreatin, Pancrelipase

B
Evidence

Digestive enzyme complex derived from porcine pancreas containing amylase, lipase, and protease. Supports digestion of proteins, fats, and carbohydrates.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Digestive support
  • Pancreatic insufficiency
  • Malabsorption

How it works

  • Breaks down proteins (protease)
  • Breaks down fats (lipase)
  • Breaks down carbohydrates (amylase)

Dosage

Typical range
500-2000 mg with meals (or by USP units)
Timing
With meals
With food
Yes - take at start of meal
Duration
As needed with meals
Special populations
Higher doses for pancreatic insufficiency

Forms

  • Porcine-derived
  • Enteric-coated
  • USP units

Safety

Common side effects

  • Nausea
  • Abdominal discomfort
  • Diarrhea at high doses

Contraindications

  • Acute pancreatitis
  • Pork allergy

Products containing Pancreatin

Top-scoring supplements in our catalog that list Pancreatin on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Multi Enzyme
87
Thorne
Pancreatic Enzymes
85
Thorne
Advanced Digestive Enzymes
84
See all products →

Evidence notes

Well-established for pancreatic insufficiency; moderate evidence for general digestive support

Grade B: Some human trials support key claims; further confirmation needed.

Related in Digestive Enzyme

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.