Ranked by evidence
Best Mood Supplements
The 6 highest-scoring mood supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.
Scored by the Formulate Research Team · Last reviewed July 2026
- 1
Thorne5-HTP (formerly 5-Hydroxytryptophan)High-quality creatine for lean muscle mass, endurance, cellular energy, and brain function* 5-HTP increases serotonin levels to promote restful sleep, manage stress, and decreas…
89A - 2
Nutricost5-HTP Capsules120 Vegetarian Capsules of High Quality 5-HTP 100 or 200mg Per Vegetarian Capsule 3rd Party Tested by ISO-Accredited Laboratories Non-GMO, Gluten Free, Vegetarian Made in a GMP…
88A - 3
Nutricost5-HTP Powder25 Grams of 5-HTP Powder Per Bottle High Quality 5-HTP Powder & 3rd Party Tested 300mg Per Serving 83 Servings Per Bottle Serving Size: 1 Scoop (Included) Made in a GMP Comp…
88A - 4
ThorneEmotion Balance SupportA multi-faceted formula of nutrients and botanicals designed to safely enhance mood and cognition* Emotion Balance Support combines several mood-enhancing nutrients and botanica…
87A - 5
ThornePharmaGABA-100Contains natural-source GABA, a brain chemical to promote a calm state of mind and restful sleep* PharmaGABA features a natural source of the inhibitory neurotransmitter – GABA.…
83A- - 6
ThornePharmaGABA-250Contains natural-source GABA, a brain chemical to promote a calm state of mind and restful sleep* PharmaGABA features a natural source of the inhibitory neurotransmitter – GABA.…
83A-
Frequently asked questions
What is the best mood supplement?
Thorne 5-HTP (formerly 5-Hydroxytryptophan) is Formulate's highest-scoring mood supplement at 89/100 (grade A). High-quality creatine for lean muscle mass, endurance, cellular energy, and brain function* 5-HTP increases serotonin levels to promote restful sleep, manage stress, and decreas…
How does Formulate rank mood supplements?
Each product is scored 0–100 by an automated rubric covering evidence quality, dose accuracy, bioavailable form, label transparency, safety, and manufacturing. Rankings reflect the formula on the label — not advertising or sponsorships.
How many mood supplements were compared?
This ranking shows the top 6 mood products Formulate has scored. Browse the full catalog for every product and its breakdown.
Best supplements by category
How these are ranked
Every mood product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.
Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.