5-HTP (formerly 5-Hydroxytryptophan)
Scored by the Formulate Research Team · Last reviewed May 2026
Overview: Thorne 5-HTP (formerly 5-Hydroxytryptophan)
High-quality creatine for lean muscle mass, endurance, cellular energy, and brain function* 5-HTP increases serotonin levels to promote restful sleep, manage stress, and decrease sugar cravings.* It contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.
Score Breakdown
Formulate scores every product across six weighted dimensions. Each dimension is graded independently — hover or tap to see what drove each component.
Ingredients per Serving
| Ingredient | Amount |
|---|---|
| 5-Hydroxytryptophan | 300 mg |
| Vitamin B6Pyridoxal 5'-Phosphate | 20.4 mg |
Certifications & Testing
Other Ingredients
Hypromellose (derived from cellulose) capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide
Recommended Use
Take 1-2 capsules three times daily or as recommended by your health-care practitioner.
Warnings
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY WARNING If pregnant or nursing, do not use this product. INTERACTIONS 5-HTP should be used with caution in an individual currently being treated with an SSRI, MAO inhibitor, or other antidepressant medication.
Frequently Asked Questions
What is Thorne 5-HTP (formerly 5-Hydroxytryptophan)'s Formulate score?
Thorne 5-HTP (formerly 5-Hydroxytryptophan) scores 91 out of 100 (grade A) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.
Is Thorne 5-HTP (formerly 5-Hydroxytryptophan) worth it?
Thorne 5-HTP (formerly 5-Hydroxytryptophan) scores 91/100 (grade A). That puts it in Formulate's top tier: its ingredient doses, forms, and label transparency hold up against the clinical evidence, and it carries credible third-party testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.
What's in Thorne 5-HTP (formerly 5-Hydroxytryptophan)?
Each serving contains 5-Hydroxytryptophan (300 mg), Vitamin B6 (20.4 mg). Serving size: 2 Capsules. 45 servings per container.
How do I take 5-htp (formerly 5-hydroxytryptophan)?
Take 1-2 capsules three times daily or as recommended by your health-care practitioner.
Who makes 5-HTP (formerly 5-Hydroxytryptophan)?
5-HTP (formerly 5-Hydroxytryptophan) is made by Thorne. See Formulate's full grade and product lineup for Thorne on its brand page.
Is Thorne 5-HTP (formerly 5-Hydroxytryptophan) third-party tested?
Thorne lists the following certifications and testing for this product: NSF Certified, Gluten Free, Dairy Free, Soy Free, Thorne Verified, Natural Flavors, Natural Colors, GMP Certified.
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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.