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Ranked by evidence

Best B Vitamins Supplements

The 10 highest-scoring b vitamins supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.

Scored by the Formulate Research Team · Last reviewed July 2026

  1. 1
    Thorne
    5-MTHF 5 mg

    Support heart health, fetal development, nervous system, and mood with 5-MTHF* 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brai…

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    96A
  2. 2
    Thorne
    Vitamin B12

    Active form of vitamin B12 that supports heart and nerve health, normal circadian rhythms, and healthy methylation* Vitamin B12 as methylcobalamin contains an active, tissue-rea…

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    96A
  3. 3
    Thorne
    Methyl-Guard®

    Supports methylation for healthy heart, blood vessels, brain, and bones* Methyl-Guard contains betaine, 5-MTHF, methyl-B12, and P5P to support healthy methylation for cardiovasc…

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    93A
  4. 4
    Natural Factors
    No Flush Niacin 500 mg

    Strongest on safety/redundancy (100/100).

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    93A
  5. 5
    Thorne
    Niacinamide

    A form of vitamin B3 that provides cellular protection and supports joints, skin, and restful sleep* Niacinamide, a non-flushing form of vitamin B3, supports joint and skin heal…

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    92A
  6. 6
    NOW Foods
    Niacinamide

    Strongest on evidence quality (100/100).

    Find on Amazon
    92A
  7. 7
    NOW Foods
    Niacin

    Strongest on evidence quality (100/100).

    Find on Amazon
    92A
  8. 8
    Thorne
    Methyl-Guard Plus

    Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation* Methyl-Guard Plus provides superior methyl donors – trimethy…

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    91A
  9. 9
    Pure Encapsulations
    B-Complex liquid

    Strongest on transparency (100/100).

    Find on Amazon
    91A
  10. 10
    Natural Factors
    Niacin 100 mg

    Strongest on evidence quality (100/100).

    Find on Amazon
    91A
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Frequently asked questions

What is the best b vitamins supplement?

Thorne 5-MTHF 5 mg is Formulate's highest-scoring b vitamins supplement at 96/100 (grade A). Support heart health, fetal development, nervous system, and mood with 5-MTHF* 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brai…

How does Formulate rank b vitamins supplements?

Each product is scored 0–100 by the same automated rubric. Clinical evidence, dose accuracy and bioavailable form carry the score; manufacturing, label transparency and safety are checked separately and can only cost points. Rankings reflect the formula on the label — not advertising or sponsorships.

How many b vitamins supplements were compared?

This ranking shows the top 10 b vitamins products Formulate has scored. Browse the full catalog for every product and its breakdown.

Best supplements by category

Best MineralsBest MultivitaminsBest Amino AcidsBest AdaptogensBest Fish Oil & OmegasBest BotanicalsBest NootropicsBest Antioxidants

How these are ranked

Every b vitamins product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.

Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.