Ranked by evidence
Best B Vitamins Supplements
The 10 highest-scoring b vitamins supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.
Scored by the Formulate Research Team · Last reviewed May 2026
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Thorne5-MTHF 5 mgSupport heart health, fetal development, nervous system, and mood with 5-MTHF* 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brai…
98A - 2
ThorneVitamin B12Active form of vitamin B12 that supports heart and nerve health, normal circadian rhythms, and healthy methylation* Vitamin B12 as methylcobalamin contains an active, tissue-rea…
98A - 3
ThorneMethyl-Guard®Supports methylation for healthy heart, blood vessels, brain, and bones* Methyl-Guard contains betaine, 5-MTHF, methyl-B12, and P5P to support healthy methylation for cardiovasc…
96A - 4
ThorneNiacinamideA form of vitamin B3 that provides cellular protection and supports joints, skin, and restful sleep* Niacinamide, a non-flushing form of vitamin B3, supports joint and skin heal…
96A - 5
Thorne5-MTHF 1 mgSupport heart health, fetal development, nervous system, and mood with 5-MTHF* 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brai…
95A - 6
ThorneBiotinBiotin, vitamin B7, supports healthy metabolism, nerves, nails, hair, and skin* A high concentration of biotin, a B vitamin that promotes fingernail strength and supports skin,…
95A - 7
ThorneMethyl-Guard Plus®Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation* Methyl-Guard Plus provides superior methyl donors – trimethy…
95A - 8
ThornePyridoxal 5'-PhosphateA tissue-ready form of vitamin B6 that promotes energy production and neurotransmitter synthesis* Pyridoxal 5'-Phosphate is vitamin B6 in its most bioactive and readily usable f…
94A - 9
ThorneB-Complex #12B-vitamin complex with extra B12 and folate B-Complex #12 supports energy production and healthy neurological function.* Unlike many multi-B vitamins, it contains the active for…
92A - 10
ThorneB-Complex #6A complete B complex formula designed for the unique needs of athletes and women* B-Complex #6 contains a balance of essential B vitamins, including methylated B12 and folate, w…
92A
Frequently asked questions
What is the best b vitamins supplement?
Thorne 5-MTHF 5 mg is Formulate's highest-scoring b vitamins supplement at 98/100 (grade A). Support heart health, fetal development, nervous system, and mood with 5-MTHF* 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brai…
How does Formulate rank b vitamins supplements?
Each product is scored 0–100 by an automated rubric covering evidence quality, dose accuracy, bioavailable form, label transparency, safety, and manufacturing. Rankings reflect the formula on the label — not advertising or sponsorships.
How many b vitamins supplements were compared?
This ranking shows the top 10 b vitamins products Formulate has scored. Browse the full catalog for every product and its breakdown.
Best supplements by category
How these are ranked
Every b vitamins product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.
Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.