Calcium binds to levothyroxine (Synthroid) in the gut, reducing absorption by up to 60%. This can lead to subtherapeutic thyroid levels and hypothyroid symptoms.
Recommendation
Take thyroid medication at least 4 hours before or after calcium supplements.
Timing
Separate by 4+ hours; thyroid med first thing in morning
Sources
— Thyroid
— PMID: 7704434
— PMID: 15574620
Frequently Asked Questions
Can I take calcium and thyroid medication together?
Calcium blocks thyroid medication absorption. Take thyroid medication at least 4 hours before or after calcium supplements.
How should I time calcium and thyroid medication?
Separate by 4+ hours; thyroid med first thing in morning
Is this interaction dangerous?
This interaction is rated “Warning” by Formulate. Calcium binds to levothyroxine (Synthroid) in the gut, reducing absorption by up to 60%. This can lead to subtherapeutic thyroid levels and hypothyroid symptoms.
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