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calcium and thyroid medication

Calcium blocks thyroid medication absorption

What's happening

Calcium binds to levothyroxine (Synthroid) in the gut, reducing absorption by up to 60%. This can lead to subtherapeutic thyroid levels and hypothyroid symptoms.

Recommendation

Take thyroid medication at least 4 hours before or after calcium supplements.

Timing

Separate by 4+ hours; thyroid med first thing in morning

Sources

  • Thyroid
  • PMID: 7704434
  • PMID: 15574620

Frequently Asked Questions

Can I take calcium and thyroid medication together?

Calcium blocks thyroid medication absorption. Take thyroid medication at least 4 hours before or after calcium supplements.

How should I time calcium and thyroid medication?

Separate by 4+ hours; thyroid med first thing in morning

Is this interaction dangerous?

This interaction is rated “Warning” by Formulate. Calcium binds to levothyroxine (Synthroid) in the gut, reducing absorption by up to 60%. This can lead to subtherapeutic thyroid levels and hypothyroid symptoms.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.