Weight Management
Yohimbine
Also known as: Pausinystalia yohimbe, Yohimbe bark, Yohimbine (Sexual Function), Yohimbine HCL
Alpha-2 antagonist for stubborn fat. Effective but significant side effects.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Stubborn fat loss
- Fasted exercise
- Libido
How it works
- Blocks alpha-2 receptors
- Enhances fasted fat burning
- Increases norepinephrine
Dosage
- Typical range
- 2.5-20mg (start very low)
- Timing
- Fasted morning
- With food
- NO - food blocks effects
- Duration
- During cutting phases
- Special populations
- Advanced, stubborn fat areas
Forms
- Capsule (HCl)
Safety
Common side effects
- Anxiety
- Rapid heartbeat
- Sweating
- Nausea
Contraindications
- Anxiety disorders
- Heart conditions
- Hypertension
- MAOIs
Evidence notes
Good evidence but narrow use case
Grade B: Some human trials support key claims; further confirmation needed.
Related in Weight Management
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.