Weight Management
Synephrine (Bitter Orange)
Also known as: Bitter orange, Citrus aurantium, p-Synephrine
Citrus extract for thermogenesis. Similar to ephedrine but supposedly safer.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Synephrine (Bitter Orange) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | NutraBio ThermoFuel V9 | 80 A- | $0.62 |
| 2 | Gaia Herbs Sinus & Lung Supreme | 64 B- | $0.52 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Synephrine (Bitter Orange) should I take?
The typical range is 10-50mg synephrine. Cycle use
When should I take Synephrine (Bitter Orange)?
Morning or pre-workout. Either.
Which form of Synephrine (Bitter Orange) is best?
Capsule — Often in fat burner stacks.
Is Synephrine (Bitter Orange) safe?
Commonly reported: Increased heart rate, Anxiety, Headache. Serious warnings: Cardiovascular concerns especially with caffeine. No major concerns
Which Synephrine (Bitter Orange) supplement scores highest?
NutraBio ThermoFuel V9, at 80/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Thermogenesis
- Energy
- Fat oxidation
How it works
- Binds beta-3 adrenergic receptors
- Increases metabolic rate
- Lipolytic effects
Dosage
- Typical range
- 10-50mg synephrine
- Timing
- Morning or pre-workout
- With food
- Either
- Duration
- Cycle use
- Special populations
- Fat loss with stimulant tolerance
Forms
- Capsule
Safety
Common side effects
- Increased heart rate
- Anxiety
- Headache
Contraindications
- Heart conditions
- Hypertension
- Anxiety
Products containing Synephrine (Bitter Orange)
Top-scoring supplements in our catalog that list Synephrine (Bitter Orange) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Modest evidence, safety concerns debated
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Weight Management
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.