Weight Management
Synephrine (Bitter Orange)
Also known as: Bitter orange, Citrus aurantium, p-Synephrine
Citrus extract for thermogenesis. Similar to ephedrine but supposedly safer.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Thermogenesis
- Energy
- Fat oxidation
How it works
- Binds beta-3 adrenergic receptors
- Increases metabolic rate
- Lipolytic effects
Dosage
- Typical range
- 10-50mg synephrine
- Timing
- Morning or pre-workout
- With food
- Either
- Duration
- Cycle use
- Special populations
- Fat loss with stimulant tolerance
Forms
- Capsule
Safety
Common side effects
- Increased heart rate
- Anxiety
- Headache
Contraindications
- Heart conditions
- Hypertension
- Anxiety
Evidence notes
Modest evidence, safety concerns debated
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Weight Management
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.