Weight Management

Synephrine (Bitter Orange)

Also known as: Bitter orange, Citrus aurantium, p-Synephrine

Evidence

Citrus extract for thermogenesis. Similar to ephedrine but supposedly safer.

Primary uses

Thermogenesis
Energy
Fat oxidation

How it works

Binds beta-3 adrenergic receptors
Increases metabolic rate
Lipolytic effects

Dosage

Typical range: 10-50mg synephrine
Timing: Morning or pre-workout
With food: Either
Duration: Cycle use
Special populations: Fat loss with stimulant tolerance

Forms

Capsule

Safety

Common side effects

Increased heart rate
Anxiety
Headache

Contraindications

Heart conditions
Hypertension
Anxiety

Evidence notes

Modest evidence, safety concerns debated

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Weight Management

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.