Mineral
Selenium (as High Selenium Yeast)
Also known as: selenized yeast, selenium yeast, organic selenium
Selenium is an essential trace mineral that acts as a cofactor for selenoproteins, including glutathione peroxidase, a powerful antioxidant enzyme. High selenium yeast is an organic form containing selenium incorporated into yeast proteins.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Selenium (as High Selenium Yeast) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Selenium | 96 A | $0.23 |
| 2 | Pure Encapsulations Selenium (citrate) | 94 A | $0.22 |
| 3 | Pure Encapsulations Selenium (selenomethionine) | 94 A | $0.24 |
| 4 | Nutricost Selenium Capsules | 94 A | $0.06 |
| 5 | Life Extension Se-Methyl L-Selenocysteine | 94 A | $0.09 |
| 6 | Natural Factors SelenoExcell Selenium | 92 A | $0.15 |
| 7 | Life Extension Super Selenium Complex & Vitamin E | 91 A | $0.10 |
| 8 | Thorne Thyroid Health Complex | 90 A | $0.33 |
| 9 | NOW Foods NAC | 89 A | $0.12 |
| 10 | MegaFood Skin, Nails & Hair 2 | 89 A | $0.87 |
| 11 | Thorne Advanced Nutrients | 88 A | $2.40 |
| 12 | Thorne Basic Nutrients 2/Day | 88 A | $0.60 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Selenium (as High Selenium Yeast) should I take?
The typical range is 55-200 mcg daily. ongoing for general health; avoid exceeding 400 mcg daily
When should I take Selenium (as High Selenium Yeast)?
any time of day. can be taken with or without food.
Which form of Selenium (as High Selenium Yeast) is best?
high selenium yeast.
Is Selenium (as High Selenium Yeast) safe?
Commonly reported: garlic odor on breath (at high doses), hair/nail fragility (toxicity sign).
Which Selenium (as High Selenium Yeast) supplement scores highest?
Thorne Selenium, at 96/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- antioxidant defense
- thyroid health
- immune function
- cardiovascular health
How it works
- cofactor for glutathione peroxidase and other selenoproteins
- protects against oxidative stress
- supports thyroid hormone metabolism
- regulates immune responses
Dosage
- Typical range
- 55-200 mcg daily
- Timing
- any time of day
- With food
- can be taken with or without food
- Duration
- ongoing for general health; avoid exceeding 400 mcg daily
- Special populations
- pregnant/nursing women: 60-70 mcg daily; those with autoimmune thyroid disease should consult provider
Forms
- high selenium yeast· 70/100
Safety
Common side effects
- garlic odor on breath (at high doses)
- hair/nail fragility (toxicity sign)
Contraindications
- do not exceed 400 mcg daily long-term; Hashimoto's thyroiditis (may require caution with high doses)
Products containing Selenium (as High Selenium Yeast)
Top-scoring supplements in our catalog that list Selenium (as High Selenium Yeast) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Selenium has good evidence for antioxidant and thyroid support. Selenized yeast provides selenium in a bioavailable organic form, showing favorable absorption and retention compared to inorganic selenite.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.