Mineral
Manganese (as Manganese Sulfate)
Also known as: Manganese, Manganese Sulfate, Mn
Manganese is an essential trace mineral involved in bone development, carbohydrate metabolism, and antioxidant defense through manganese superoxide dismutase. It serves as a cofactor for numerous enzymes.
Daily target & upper limit
2.3 mg / day · UL 11 mgManganese (as Manganese Sulfate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Manganese (as Manganese Sulfate) dosage reference →Primary uses
- Cofactor for manganese superoxide dismutase and other enzymes
- Bone formation and remodeling
- Glucose metabolism and insulin function
- Antioxidant protection
How it works
- Acts as a metalloenzyme cofactor for multiple oxidoreductases
- Component of manganese superoxide dismutase (MnSOD) in mitochondria
- Regulates gene expression and cell signaling pathways
Dosage
- Typical range
- 1.8–2.3 mg daily (RDA for adults)
- Timing
- With meals
- With food
- Recommended; food improves absorption and reduces GI upset
- Duration
- Safe at recommended intake; toxicity risk increases significantly above 11 mg/day
- Special populations
- Workers with chronic occupational inhalation exposure (manganese dust) are at risk for manganism; oral supplementation at normal doses is not associated with this risk
Forms
- Manganese sulfate· 70/100
- Manganese gluconate· 70/100
- Manganese citrate· 70/100
Safety
Common side effects
- Generally well-tolerated at recommended doses
- High doses may cause GI upset
Contraindications
- History of manganism or chronic manganese exposure
- Liver disease (impairs manganese excretion)
Products containing Manganese (as Manganese Sulfate)
Top-scoring supplements in our catalog that list Manganese (as Manganese Sulfate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Manganese is an established essential mineral with well-documented enzymatic functions and metabolic roles. Deficiency is rare but causes measurable impairment in bone health and metabolism.
Grade A: Multiple well-designed human trials support the main claims.
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