Mineral

Manganese (as Manganese Sulfate)

Also known as: Manganese, Manganese Sulfate, Mn

Evidence

Manganese is an essential trace mineral involved in bone development, carbohydrate metabolism, and antioxidant defense through manganese superoxide dismutase. It serves as a cofactor for numerous enzymes.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

2.3 mg / day · UL 11 mg

Manganese (as Manganese Sulfate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

Cofactor for manganese superoxide dismutase and other enzymes
Bone formation and remodeling
Glucose metabolism and insulin function
Antioxidant protection

How it works

Acts as a metalloenzyme cofactor for multiple oxidoreductases
Component of manganese superoxide dismutase (MnSOD) in mitochondria
Regulates gene expression and cell signaling pathways

Dosage

Typical range: 1.8–2.3 mg daily (RDA for adults)
Timing: With meals
With food: Recommended; food improves absorption and reduces GI upset
Duration: Safe at recommended intake; toxicity risk increases significantly above 11 mg/day
Special populations: Workers with chronic occupational inhalation exposure (manganese dust) are at risk for manganism; oral supplementation at normal doses is not associated with this risk

Forms

Manganese sulfate· 70/100
Manganese gluconate· 70/100
Manganese citrate· 70/100

Safety

Common side effects

Generally well-tolerated at recommended doses
High doses may cause GI upset

Contraindications

History of manganism or chronic manganese exposure
Liver disease (impairs manganese excretion)

Products containing Manganese (as Manganese Sulfate)

Top-scoring supplements in our catalog that list Manganese (as Manganese Sulfate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Advanced Nutrients

Thorne

Basic Nutrients 2/Day

Evidence notes

Manganese is an established essential mineral with well-documented enzymatic functions and metabolic roles. Deficiency is rare but causes measurable impairment in bone health and metabolism.

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.