Mineral
Manganese (as Manganese Sulfate)
Also known as: Manganese, Manganese Sulfate, Mn
Manganese is an essential trace mineral involved in bone development, carbohydrate metabolism, and antioxidant defense through manganese superoxide dismutase. It serves as a cofactor for numerous enzymes.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Manganese (as Manganese Sulfate) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Advanced Nutrients | 88 A | $2.40 |
| 2 | Thorne Basic Nutrients 2/Day | 88 A | $0.60 |
| 3 | Thorne Basic Prenatal | 88 A | $1.23 |
| 4 | Thorne Men's Multi 50+ | 88 A | $1.87 |
| 5 | Pure Encapsulations Glucosamine Chondroitin with Manganese | 87 A | $0.54 |
| 6 | Garden of Life Vitamin Code 50 & Wiser Women | 87 A | $1.01 |
| 7 | Thorne MediClear-SGS™ - Vanilla | 86 A- | $2.10 |
| 8 | Transparent Labs Multivitamin | 86 A- | $1.33 |
| 9 | Seed AM-02™ Energy + Focus Supplement | 86 A- | $1.17 |
| 10 | Garden of Life Organics Women's Multi 40+ | 86 A- | $1.07 |
| 11 | Garden of Life Vitamin Code Raw One for Men | 86 A- | $0.41 |
| 12 | Garden of Life Organics Men's Multi | 86 A- | $1.16 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Manganese (as Manganese Sulfate) should I take?
The typical range is 1.8–2.3 mg daily (RDA for adults). Safe at recommended intake; toxicity risk increases significantly above 11 mg/day
When should I take Manganese (as Manganese Sulfate)?
With meals. Recommended; food improves absorption and reduces GI upset.
Which form of Manganese (as Manganese Sulfate) is best?
Manganese sulfate. Other forms in the catalog: Manganese gluconate, Manganese citrate.
Is Manganese (as Manganese Sulfate) safe?
Commonly reported: Generally well-tolerated at recommended doses, High doses may cause GI upset.
Which Manganese (as Manganese Sulfate) supplement scores highest?
Thorne Advanced Nutrients, at 88/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Daily target & upper limit
2.3 mg / day · UL 11 mgManganese (as Manganese Sulfate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Manganese (as Manganese Sulfate) dosage reference →Primary uses
- Cofactor for manganese superoxide dismutase and other enzymes
- Bone formation and remodeling
- Glucose metabolism and insulin function
- Antioxidant protection
How it works
- Acts as a metalloenzyme cofactor for multiple oxidoreductases
- Component of manganese superoxide dismutase (MnSOD) in mitochondria
- Regulates gene expression and cell signaling pathways
Dosage
- Typical range
- 1.8–2.3 mg daily (RDA for adults)
- Timing
- With meals
- With food
- Recommended; food improves absorption and reduces GI upset
- Duration
- Safe at recommended intake; toxicity risk increases significantly above 11 mg/day
- Special populations
- Workers with chronic occupational inhalation exposure (manganese dust) are at risk for manganism; oral supplementation at normal doses is not associated with this risk
Forms
- Manganese sulfate· 70/100
- Manganese gluconate· 70/100
- Manganese citrate· 70/100
Safety
Common side effects
- Generally well-tolerated at recommended doses
- High doses may cause GI upset
Contraindications
- History of manganism or chronic manganese exposure
- Liver disease (impairs manganese excretion)
Products containing Manganese (as Manganese Sulfate)
Top-scoring supplements in our catalog that list Manganese (as Manganese Sulfate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Manganese is an established essential mineral with well-documented enzymatic functions and metabolic roles. Deficiency is rare but causes measurable impairment in bone health and metabolism.
Grade A: Multiple well-designed human trials support the main claims.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.