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Herbal Extract

Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid

Also known as: Sage extract, Salvia officinalis, Garden sage, Common sage

C
Evidence

Salvia officinalis (garden sage) is a traditional Mediterranean herb containing rosmarinic acid and other polyphenols with demonstrated antioxidant and anti-inflammatory properties. Limited but emerging evidence suggests potential cognitive and memory-supporting effects, though human clinical data remains modest.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Cognitive support
  • Memory enhancement
  • Antioxidant protection
  • Mood support

How it works

  • Rosmarinic acid-mediated antioxidant activity
  • Acetylcholinesterase inhibition (partial)
  • Neuroprotection via polyphenol content
  • Anti-inflammatory signaling

Dosage

Typical range
300-600 mg daily (of standardized extract)
Timing
With meals for better absorption and reduced GI irritation
With food
Recommended to enhance absorption of lipophilic compounds
Duration
Effects may take 2-4 weeks of consistent use; traditional use spans months
Special populations
Pregnant/nursing women should consult a healthcare provider before use; may interact with certain medications

Forms

  • Powder (dried leaf extract)· 70/100
  • Capsule· 70/100
  • Liquid extract· 70/100
  • Tea· 70/100

Safety

Common side effects

  • Mild gastrointestinal upset
  • Dizziness (rare)
  • Allergic reactions (very rare)

Contraindications

  • Pregnancy and breastfeeding (insufficient safety data)
  • Seizure disorders (theoretical risk; high doses traditionally contraindicated)
  • Hypersensitivity to Salvia species

Evidence notes

Human cognitive studies are limited and small; most evidence derives from in vitro and animal models. A few clinical trials show modest benefits for memory and attention, but sample sizes are small and designs vary. Rosmarinic acid content is well-characterized chemically, but clinical efficacy requires more robust RCT evidence.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.