Herbal Extract
Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid
Also known as: Sage extract, Salvia officinalis, Garden sage, Common sage
Salvia officinalis (garden sage) is a traditional Mediterranean herb containing rosmarinic acid and other polyphenols with demonstrated antioxidant and anti-inflammatory properties. Limited but emerging evidence suggests potential cognitive and memory-supporting effects, though human clinical data remains modest.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations PhytoBalance II | 82 A- | $0.47 |
| 2 | Life Extension Cognitex Elite Pregnenolone | 81 A- | $1.48 |
| 3 | Vital Nutrients Menopause Support | 74 B+ | $0.70 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid should I take?
The typical range is 300-600 mg daily (of standardized extract). Effects may take 2-4 weeks of consistent use; traditional use spans months
When should I take Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid?
With meals for better absorption and reduced GI irritation. Recommended to enhance absorption of lipophilic compounds.
Which form of Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid is best?
Powder (dried leaf extract). Other forms in the catalog: Capsule, Liquid extract, Tea.
Is Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid safe?
Commonly reported: Mild gastrointestinal upset, Dizziness (rare), Allergic reactions (very rare).
Which Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid supplement scores highest?
Pure Encapsulations PhytoBalance II, at 82/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cognitive support
- Memory enhancement
- Antioxidant protection
- Mood support
How it works
- Rosmarinic acid-mediated antioxidant activity
- Acetylcholinesterase inhibition (partial)
- Neuroprotection via polyphenol content
- Anti-inflammatory signaling
Dosage
- Typical range
- 300-600 mg daily (of standardized extract)
- Timing
- With meals for better absorption and reduced GI irritation
- With food
- Recommended to enhance absorption of lipophilic compounds
- Duration
- Effects may take 2-4 weeks of consistent use; traditional use spans months
- Special populations
- Pregnant/nursing women should consult a healthcare provider before use; may interact with certain medications
Forms
- Powder (dried leaf extract)· 70/100
- Capsule· 70/100
- Liquid extract· 70/100
- Tea· 70/100
Safety
Common side effects
- Mild gastrointestinal upset
- Dizziness (rare)
- Allergic reactions (very rare)
Contraindications
- Pregnancy and breastfeeding (insufficient safety data)
- Seizure disorders (theoretical risk; high doses traditionally contraindicated)
- Hypersensitivity to Salvia species
Products containing Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid
Top-scoring supplements in our catalog that list Salvia officinalis Extract (Sage Leaf) - 2.5% Rosmarinic Acid on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Human cognitive studies are limited and small; most evidence derives from in vitro and animal models. A few clinical trials show modest benefits for memory and attention, but sample sizes are small and designs vary. Rosmarinic acid content is well-characterized chemically, but clinical efficacy requires more robust RCT evidence.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.