Herbal Extract

Ampelopsis grossedentata Extract (Dihydromyricetin)

Also known as: Dihydromyricetin, DHM, Ampelex, Vitis grossedentata extract

Evidence

Ampelopsis grossedentata extract is a plant-derived source of dihydromyricetin, a flavonoid traditionally used in Chinese medicine with emerging research on alcohol metabolism and antioxidant activity. Limited human clinical evidence exists; most studies are preclinical or conducted in animal models.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Alcohol hangover support
Antioxidant support
Liver health
Hangover prevention

How it works

ALDH2 enzyme inhibition (theoretically reducing acetaldehyde accumulation)
Antioxidant and free radical scavenging
Anti-inflammatory activity
Potential liver-protective effects

Dosage

Typical range: 100-600 mg daily
Timing: Typically taken before or with alcohol consumption for hangover support; general use timing unclear
With food: May be taken with or without food; no strong evidence either way
Duration: Acute use: single dose before alcohol. Chronic safety data limited.
Special populations: Pregnant/nursing women: insufficient data; avoid. Liver disease: consult healthcare provider.

Forms

Capsule· 70/100
Powder· 70/100
Tablet· 70/100

Safety

Common side effects

Headache
Nausea
Dizziness (rare)

Contraindications

Pregnancy and lactation
Severe liver disease (insufficient data)
Known hypersensitivity to Ampelopsis or plant components

Products containing Ampelopsis grossedentata Extract (Dihydromyricetin)

Top-scoring supplements in our catalog that list Ampelopsis grossedentata Extract (Dihydromyricetin) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Nootropics Depot

Alcohol Defense Capsule

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Evidence notes

Mechanism supported by in vitro and animal studies; limited high-quality human RCTs. One small human hangover study showed promise, but larger, well-controlled trials needed. Traditional use in Chinese medicine but not extensively researched in Western literature.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.