Skip to main content

Herbal Extract

Ampelopsis grossedentata Extract (Dihydromyricetin)

Also known as: Dihydromyricetin, DHM, Ampelex, Vitis grossedentata extract

C
Evidence

Ampelopsis grossedentata extract is a plant-derived source of dihydromyricetin, a flavonoid traditionally used in Chinese medicine with emerging research on alcohol metabolism and antioxidant activity. Limited human clinical evidence exists; most studies are preclinical or conducted in animal models.

Primary uses

  • Alcohol hangover support
  • Antioxidant support
  • Liver health
  • Hangover prevention

How it works

  • ALDH2 enzyme inhibition (theoretically reducing acetaldehyde accumulation)
  • Antioxidant and free radical scavenging
  • Anti-inflammatory activity
  • Potential liver-protective effects

Dosage

Typical range
100-600 mg daily
Timing
Typically taken before or with alcohol consumption for hangover support; general use timing unclear
With food
May be taken with or without food; no strong evidence either way
Duration
Acute use: single dose before alcohol. Chronic safety data limited.
Special populations
Pregnant/nursing women: insufficient data; avoid. Liver disease: consult healthcare provider.

Forms

  • Capsule· 70/100
  • Powder· 70/100
  • Tablet· 70/100

Safety

Common side effects

  • Headache
  • Nausea
  • Dizziness (rare)

Contraindications

  • Pregnancy and lactation
  • Severe liver disease (insufficient data)
  • Known hypersensitivity to Ampelopsis or plant components

Evidence notes

Mechanism supported by in vitro and animal studies; limited high-quality human RCTs. One small human hangover study showed promise, but larger, well-controlled trials needed. Traditional use in Chinese medicine but not extensively researched in Western literature.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Herbal Extract

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.