Hormone Support
Micronized Pregnenolone
Also known as: Pregnenolone, PREG, 3β-Hydroxy-5-pregnenolone, Pregnenolone micronized
A steroid hormone precursor derived from cholesterol, positioned as the upstream substrate for both DHEA and progesterone pathways. Micronization improves bioavailability.
Primary uses
- Hormone balance support
- Memory and cognitive function
- Mood support
- Energy and vitality
How it works
- Precursor to DHEA and progesterone
- Neurosteroid effects on brain function
- Potential anti-inflammatory effects
- Supports steroid hormone synthesis
Dosage
- Typical range
- 50-100 mg daily
- Timing
- Morning with food
- With food
- With food, preferably containing fat, to enhance absorption
- Duration
- Effects may take 4-8 weeks to manifest; long-term safety data in healthy adults is limited
- Special populations
- Not recommended during pregnancy/nursing; use cautiously in hormone-sensitive conditions
Forms
- Micronized powder· 70/100
- Capsule· 70/100
Safety
Common side effects
- Acne or skin irritation
- Hair growth changes
- Sleep disruption if taken late
- Mood changes
Contraindications
- Hormone-sensitive cancers (breast, prostate)
- Pregnancy and nursing
- Undiagnosed hormone imbalances
- Blood clotting disorders
Evidence notes
Limited human RCT evidence; most data from preclinical and animal studies. Few rigorous studies in healthy adults. Micronization may improve absorption but clinical significance unclear.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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