Hormone Support

Micronized Pregnenolone

Also known as: Pregnenolone, PREG, 3β-Hydroxy-5-pregnenolone, Pregnenolone micronized

Evidence

A steroid hormone precursor derived from cholesterol, positioned as the upstream substrate for both DHEA and progesterone pathways. Micronization improves bioavailability.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Hormone balance support
Memory and cognitive function
Mood support
Energy and vitality

How it works

Precursor to DHEA and progesterone
Neurosteroid effects on brain function
Potential anti-inflammatory effects
Supports steroid hormone synthesis

Dosage

Typical range: 50-100 mg daily
Timing: Morning with food
With food: With food, preferably containing fat, to enhance absorption
Duration: Effects may take 4-8 weeks to manifest; long-term safety data in healthy adults is limited
Special populations: Not recommended during pregnancy/nursing; use cautiously in hormone-sensitive conditions

Forms

Micronized powder· 70/100
Capsule· 70/100

Safety

Common side effects

Acne or skin irritation
Hair growth changes
Sleep disruption if taken late
Mood changes

Contraindications

Hormone-sensitive cancers (breast, prostate)
Pregnancy and nursing
Undiagnosed hormone imbalances
Blood clotting disorders

Products containing Micronized Pregnenolone

Top-scoring supplements in our catalog that list Micronized Pregnenolone on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Limited human RCT evidence; most data from preclinical and animal studies. Few rigorous studies in healthy adults. Micronization may improve absorption but clinical significance unclear.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.