Hormone Support
Micronized Pregnenolone
Also known as: Pregnenolone, PREG, 3β-Hydroxy-5-pregnenolone, Pregnenolone micronized
A steroid hormone precursor derived from cholesterol, positioned as the upstream substrate for both DHEA and progesterone pathways. Micronization improves bioavailability.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Micronized Pregnenolone product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nootropics Depot Eurycomax Capsules | 86 A- | $2.17 |
| 2 | Double Wood Pregnenolone Supplement | 83 A- | $0.33 |
| 3 | Life Extension Pregnenolone | 83 A- | $0.24 |
| 4 | Nootropics Depot Cistamax Capsules | 82 A- | $0.50 |
| 5 | Life Extension Cognitex Elite Pregnenolone | 81 A- | $1.48 |
| 6 | Vital Nutrients Pregnenolone 10mg | 76 B+ | $0.25 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Micronized Pregnenolone should I take?
The typical range is 50-100 mg daily. Effects may take 4-8 weeks to manifest; long-term safety data in healthy adults is limited
When should I take Micronized Pregnenolone?
Morning with food. With food, preferably containing fat, to enhance absorption.
Which form of Micronized Pregnenolone is best?
Micronized powder. Other forms in the catalog: Capsule.
Is Micronized Pregnenolone safe?
Commonly reported: Acne or skin irritation, Hair growth changes, Sleep disruption if taken late, Mood changes.
Which Micronized Pregnenolone supplement scores highest?
Nootropics Depot Eurycomax Capsules, at 86/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Hormone balance support
- Memory and cognitive function
- Mood support
- Energy and vitality
How it works
- Precursor to DHEA and progesterone
- Neurosteroid effects on brain function
- Potential anti-inflammatory effects
- Supports steroid hormone synthesis
Dosage
- Typical range
- 50-100 mg daily
- Timing
- Morning with food
- With food
- With food, preferably containing fat, to enhance absorption
- Duration
- Effects may take 4-8 weeks to manifest; long-term safety data in healthy adults is limited
- Special populations
- Not recommended during pregnancy/nursing; use cautiously in hormone-sensitive conditions
Forms
- Micronized powder· 70/100
- Capsule· 70/100
Safety
Common side effects
- Acne or skin irritation
- Hair growth changes
- Sleep disruption if taken late
- Mood changes
Contraindications
- Hormone-sensitive cancers (breast, prostate)
- Pregnancy and nursing
- Undiagnosed hormone imbalances
- Blood clotting disorders
Products containing Micronized Pregnenolone
Top-scoring supplements in our catalog that list Micronized Pregnenolone on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Limited human RCT evidence; most data from preclinical and animal studies. Few rigorous studies in healthy adults. Micronization may improve absorption but clinical significance unclear.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Hormone Support
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.