Digestive
Piperine (95% from Piper nigrum seed extract)
Also known as: Black pepper extract, Piper nigrum extract, BioPerine (branded form), Piperine alkaloid
Piperine is the primary alkaloid compound in black pepper that enhances nutrient bioavailability and has thermogenic and digestive properties. It is widely used as a bioenhancer to improve absorption of other supplements.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Piperine (95% from Piper nigrum seed extract) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost KSM-66 Capsules | 96 A | $0.28 |
| 2 | Doctor's Best High Absorption CoQ10 with BioPerine, 300 mg, 90 Veggie Softgels | 95 A | $0.41 |
| 3 | Doctor's Best High Absorption CoQ10 with BioPerine, 100 mg, 60 Veggie Caps | 95 A | $0.22 |
| 4 | Nutricost DIM Capsules | 94 A | $0.17 |
| 5 | Nutricost L-Tryptophan Capsules | 94 A | $0.15 |
| 6 | NOW Foods Magnesium Glycinate with BioPerine | 93 A | $0.22 |
| 7 | Transparent Labs Fat Burner | 92 A | $0.92 |
| 8 | Pure Encapsulations Curcumin 500 with Bioperine | 92 A | $0.85 |
| 9 | Transparent Labs BULK Pre-Workout | 90 A | $1.67 |
| 10 | Nutricost Turmeric Capsules | 90 A | $0.42 |
| 11 | NutraBio Curcumin Advanced | 90 A | $1.23 |
| 12 | Nutricost Pre-Workout For Women Powder | 89 A | $0.73 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Piperine (95% from Piper nigrum seed extract) should I take?
The typical range is 5-20 mg daily (as bioenhancer); up to 15 mg per dose with target nutrients. Safe for chronic use; most bioenhancement studies use acute dosing
When should I take Piperine (95% from Piper nigrum seed extract)?
With meals containing fat-soluble substances to enhance absorption. Strongly recommended with food, especially when used as a bioenhancer.
Which form of Piperine (95% from Piper nigrum seed extract) is best?
Extract powder. Other forms in the catalog: Standardized capsule, Tablet.
Is Piperine (95% from Piper nigrum seed extract) safe?
Commonly reported: Generally well-tolerated at bioenhancer doses, Rare: GI irritation, heartburn at higher doses, Thermogenic effect may increase body temperature slightly.
Which Piperine (95% from Piper nigrum seed extract) supplement scores highest?
Nutricost KSM-66 Capsules, at 96/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Bioenhancer for nutrient absorption
- Digestive support
- Thermogenesis and metabolism
- Anti-inflammatory support
- Gastrointestinal motility
How it works
- Inhibition of intestinal glucuronidation and P-glycoprotein efflux
- Enhanced nutrient absorption in the GI tract
- Thermogenic and metabolic rate increase
- TRPV1 channel activation
- Anti-inflammatory and antioxidant activity
Dosage
- Typical range
- 5-20 mg daily (as bioenhancer); up to 15 mg per dose with target nutrients
- Timing
- With meals containing fat-soluble substances to enhance absorption
- With food
- Strongly recommended with food, especially when used as a bioenhancer
- Duration
- Safe for chronic use; most bioenhancement studies use acute dosing
- Special populations
- Use cautiously in pregnancy; avoid if sensitive to black pepper; caution in GERD or GI ulcers
Forms
- Extract powder· 70/100
- Standardized capsule· 70/100
- Tablet· 70/100
Safety
Common side effects
- Generally well-tolerated at bioenhancer doses
- Rare: GI irritation, heartburn at higher doses
- Thermogenic effect may increase body temperature slightly
Contraindications
- Active peptic ulcer disease
- Severe GERD
- Gallbladder disease (may increase bile secretion)
- Allergy to Piper nigrum or black pepper
Products containing Piperine (95% from Piper nigrum seed extract)
Top-scoring supplements in our catalog that list Piperine (95% from Piper nigrum seed extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong evidence for bioenhancement of curcumin and other compounds; human studies confirm increased nutrient absorption; moderate evidence for independent health effects; widely used in clinical practice.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.