Herbal Extract
Piper nigrum Extract (Seed) - 95% Piperine
Also known as: Black Pepper Extract, Piperine, BioPerine®, Black Pepper Alkaloid
Piperine is the primary alkaloid from black pepper seeds with potent bioavailability-enhancing properties that significantly increase the absorption of other compounds. It also has mild anti-inflammatory and metabolic support properties.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Piper nigrum Extract (Seed) - 95% Piperine product we have scored
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Piper nigrum Extract (Seed) - 95% Piperine should I take?
The typical range is 5-20 mg daily (as bioavailability enhancer); 50-200 mg for standalone use. Safe for long-term use; primarily used in combination products
When should I take Piper nigrum Extract (Seed) - 95% Piperine?
With meals or with curcumin/fat-soluble compounds. With food and fat sources for optimal effect.
Which form of Piper nigrum Extract (Seed) - 95% Piperine is best?
Powder. Other forms in the catalog: Extract, Capsule.
Is Piper nigrum Extract (Seed) - 95% Piperine safe?
Commonly reported: Gastrointestinal irritation, Mild heartburn, Mild heat sensation (at high doses).
Which Piper nigrum Extract (Seed) - 95% Piperine supplement scores highest?
Pure Encapsulations Curcumin 500 with Bioperine, at 92/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Bioavailability enhancer
- Anti-inflammatory support
- Metabolic support
- Nutrient absorption optimization
How it works
- Inhibition of hepatic and intestinal glucuronidation
- Increased intestinal permeability
- Heat production (thermogenesis)
- NF-κB pathway modulation
Dosage
- Typical range
- 5-20 mg daily (as bioavailability enhancer); 50-200 mg for standalone use
- Timing
- With meals or with curcumin/fat-soluble compounds
- With food
- With food and fat sources for optimal effect
- Duration
- Safe for long-term use; primarily used in combination products
- Special populations
- Pregnancy: use only small amounts (culinary levels); nursing: caution advised
Forms
- Powder· 70/100
- Extract· 70/100
- Capsule· 70/100
Safety
Common side effects
- Gastrointestinal irritation
- Mild heartburn
- Mild heat sensation (at high doses)
Contraindications
- Peptic ulcer disease
- Gastroesophageal reflux disease (GERD)
- Biliary disorders
- Pregnancy (high doses)
Products containing Piper nigrum Extract (Seed) - 95% Piperine
Top-scoring supplements in our catalog that list Piper nigrum Extract (Seed) - 95% Piperine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong evidence as a bioavailability enhancer; multiple studies demonstrate 1300-2000% increased absorption of curcumin. Clinical evidence supports mild anti-inflammatory effects and metabolic support. Often used as a functional excipient rather than standalone active.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.