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Herbal Extract

Piper nigrum Extract (Seed) - 95% Piperine

Also known as: Black Pepper Extract, Piperine, BioPerine®, Black Pepper Alkaloid

B
Evidence

Piperine is the primary alkaloid from black pepper seeds with potent bioavailability-enhancing properties that significantly increase the absorption of other compounds. It also has mild anti-inflammatory and metabolic support properties.

Primary uses

  • Bioavailability enhancer
  • Anti-inflammatory support
  • Metabolic support
  • Nutrient absorption optimization

How it works

  • Inhibition of hepatic and intestinal glucuronidation
  • Increased intestinal permeability
  • Heat production (thermogenesis)
  • NF-κB pathway modulation

Dosage

Typical range
5-20 mg daily (as bioavailability enhancer); 50-200 mg for standalone use
Timing
With meals or with curcumin/fat-soluble compounds
With food
With food and fat sources for optimal effect
Duration
Safe for long-term use; primarily used in combination products
Special populations
Pregnancy: use only small amounts (culinary levels); nursing: caution advised

Forms

  • Powder· 70/100
  • Extract· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Gastrointestinal irritation
  • Mild heartburn
  • Mild heat sensation (at high doses)

Contraindications

  • Peptic ulcer disease
  • Gastroesophageal reflux disease (GERD)
  • Biliary disorders
  • Pregnancy (high doses)

Evidence notes

Strong evidence as a bioavailability enhancer; multiple studies demonstrate 1300-2000% increased absorption of curcumin. Clinical evidence supports mild anti-inflammatory effects and metabolic support. Often used as a functional excipient rather than standalone active.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.