Herbal Extract
Black Pepper Extract (Piper nigrum) - Standardized to Piperine
Also known as: Piperine, BioPerine®, Black Pepper Extract, Piper nigrum fruit extract
Piperine is the alkaloid compound in black pepper that enhances nutrient absorption by increasing intestinal permeability and hepatic metabolism. It is commonly used in supplements to boost the bioavailability of other ingredients.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Black Pepper Extract (Piper nigrum) - Standardized to Piperine product we have scored
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Black Pepper Extract (Piper nigrum) - Standardized to Piperine should I take?
The typical range is 5-15 mg piperine daily. Effects on absorption are immediate; benefits accumulate with consistent use
When should I take Black Pepper Extract (Piper nigrum) - Standardized to Piperine?
With meals containing other nutrients to enhance absorption. Recommended — taken with fat-soluble nutrients and food.
Which form of Black Pepper Extract (Piper nigrum) - Standardized to Piperine is best?
95% Piperine extract (standardized). Other forms in the catalog: BioPerine® (branded form).
Is Black Pepper Extract (Piper nigrum) - Standardized to Piperine safe?
Commonly reported: Mild gastrointestinal irritation (dose-dependent), Throat irritation if inhaled, Rare: heartburn or stomach upset at high doses.
Which Black Pepper Extract (Piper nigrum) - Standardized to Piperine supplement scores highest?
Pure Encapsulations Curcumin 500 with Bioperine, at 92/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Bioavailability enhancer
- Nutrient absorption amplifier
- Thermogenic support
- Anti-inflammatory
- Gastrointestinal support
How it works
- Increases intestinal permeability and tight junction modulation
- Inhibits hepatic and intestinal metabolism (CYP3A4, P-glycoprotein)
- Enhances nutrient transport across intestinal epithelium
- Thermogenic effects via metabolic stimulation
- Mild anti-inflammatory via NF-κB pathway
Dosage
- Typical range
- 5-15 mg piperine daily
- Timing
- With meals containing other nutrients to enhance absorption
- With food
- Recommended — taken with fat-soluble nutrients and food
- Duration
- Effects on absorption are immediate; benefits accumulate with consistent use
- Special populations
- Reduce dosage or avoid in pregnancy/lactation; caution in individuals with gastric ulcers or GERD
Forms
- 95% Piperine extract (standardized)· 70/100
- BioPerine® (branded form)· 70/100
Safety
Common side effects
- Mild gastrointestinal irritation (dose-dependent)
- Throat irritation if inhaled
- Rare: heartburn or stomach upset at high doses
Contraindications
- Active peptic ulcer disease
- Severe GERD
- Pregnancy/lactation (safety unestablished)
- Bile duct obstruction
Products containing Black Pepper Extract (Piper nigrum) - Standardized to Piperine
Top-scoring supplements in our catalog that list Black Pepper Extract (Piper nigrum) - Standardized to Piperine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Well-documented bioavailability enhancement (20-30% increase in absorption of co-administered nutrients). Good safety profile and multiple human studies; most evidence is in food/nutrition context rather than disease treatment.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.