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Herbal Extract

Black Pepper Extract (Piper nigrum) - Standardized to Piperine

Also known as: Piperine, BioPerine®, Black Pepper Extract, Piper nigrum fruit extract

B
Evidence

Piperine is the alkaloid compound in black pepper that enhances nutrient absorption by increasing intestinal permeability and hepatic metabolism. It is commonly used in supplements to boost the bioavailability of other ingredients.

Primary uses

  • Bioavailability enhancer
  • Nutrient absorption amplifier
  • Thermogenic support
  • Anti-inflammatory
  • Gastrointestinal support

How it works

  • Increases intestinal permeability and tight junction modulation
  • Inhibits hepatic and intestinal metabolism (CYP3A4, P-glycoprotein)
  • Enhances nutrient transport across intestinal epithelium
  • Thermogenic effects via metabolic stimulation
  • Mild anti-inflammatory via NF-κB pathway

Dosage

Typical range
5-15 mg piperine daily
Timing
With meals containing other nutrients to enhance absorption
With food
Recommended — taken with fat-soluble nutrients and food
Duration
Effects on absorption are immediate; benefits accumulate with consistent use
Special populations
Reduce dosage or avoid in pregnancy/lactation; caution in individuals with gastric ulcers or GERD

Forms

  • 95% Piperine extract (standardized)· 70/100
  • BioPerine® (branded form)· 70/100

Safety

Common side effects

  • Mild gastrointestinal irritation (dose-dependent)
  • Throat irritation if inhaled
  • Rare: heartburn or stomach upset at high doses

Contraindications

  • Active peptic ulcer disease
  • Severe GERD
  • Pregnancy/lactation (safety unestablished)
  • Bile duct obstruction

Evidence notes

Well-documented bioavailability enhancement (20-30% increase in absorption of co-administered nutrients). Good safety profile and multiple human studies; most evidence is in food/nutrition context rather than disease treatment.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.