Herbal Extract

Black Pepper Extract (Piper nigrum) - Standardized to Piperine

Also known as: Piperine, BioPerine®, Black Pepper Extract, Piper nigrum fruit extract

Evidence

Piperine is the alkaloid compound in black pepper that enhances nutrient absorption by increasing intestinal permeability and hepatic metabolism. It is commonly used in supplements to boost the bioavailability of other ingredients.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Bioavailability enhancer
Nutrient absorption amplifier
Thermogenic support
Anti-inflammatory
Gastrointestinal support

How it works

Increases intestinal permeability and tight junction modulation
Inhibits hepatic and intestinal metabolism (CYP3A4, P-glycoprotein)
Enhances nutrient transport across intestinal epithelium
Thermogenic effects via metabolic stimulation
Mild anti-inflammatory via NF-κB pathway

Dosage

Typical range: 5-15 mg piperine daily
Timing: With meals containing other nutrients to enhance absorption
With food: Recommended — taken with fat-soluble nutrients and food
Duration: Effects on absorption are immediate; benefits accumulate with consistent use
Special populations: Reduce dosage or avoid in pregnancy/lactation; caution in individuals with gastric ulcers or GERD

Forms

95% Piperine extract (standardized)· 70/100
BioPerine® (branded form)· 70/100

Safety

Common side effects

Mild gastrointestinal irritation (dose-dependent)
Throat irritation if inhaled
Rare: heartburn or stomach upset at high doses

Contraindications

Active peptic ulcer disease
Severe GERD
Pregnancy/lactation (safety unestablished)
Bile duct obstruction

Products containing Black Pepper Extract (Piper nigrum) - Standardized to Piperine

Top-scoring supplements in our catalog that list Black Pepper Extract (Piper nigrum) - Standardized to Piperine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Well-documented bioavailability enhancement (20-30% increase in absorption of co-administered nutrients). Good safety profile and multiple human studies; most evidence is in food/nutrition context rather than disease treatment.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.