Herbal Extract
Aframomum melegueta Extract
Also known as: grains of paradise, ColorBurn®, 6-paradol, African cardamom
Aframomum melegueta is a West African spice containing 6-paradol and related pungent compounds that may modestly support thermogenesis and metabolic rate. Evidence is preliminary and limited to animal studies and small human trials.
Primary uses
- Thermogenesis support
- Metabolic rate enhancement
- Caloric expenditure
- Thermogenic support
- Metabolic enhancement
- Energy support
How it works
- TRPV1 receptor activation (thermogenesis)
- Brown adipose tissue (BAT) activation
- Metabolic rate support
Dosage
- Typical range
- 10-40 mg 6-paradol daily
- Timing
- With meals
- With food
- Take with food
- Duration
- Short-term safety established; long-term human safety data limited
- Special populations
- Pregnancy/nursing: insufficient data; caution advised
Forms
- Extract (standardized to 6-Paradol)· 70/100
- Seed extract (ColorBurn® standardized to 6-paradol)· 70/100
Safety
Common side effects
- Rare; potential for mild GI stimulation or oral pungency
Evidence notes
Evidence is limited to animal studies and a small number of preliminary human trials. 6-Paradol shows mechanistic promise via thermogenic pathways but lacks robust RCT data in humans. No large-scale clinical trials have established clear efficacy for weight management.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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