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Herbal Extract

Cissus Quadrangularis Extract

Also known as: Cissus Extract, Vitis quadrangularis, Veldt Grape, Adamant Creeper

C
Evidence

Cissus quadrangularis is a traditional plant extract standardized to ketosterones, primarily studied for bone health and joint support in both animal and limited human research. Evidence remains preliminary, with most human studies showing modest effects on bone metabolism and fracture healing.

Primary uses

  • Bone health support
  • Joint and connective tissue support
  • Fracture recovery
  • Bone density maintenance

How it works

  • Ketosterone compounds may modulate bone-specific alkaline phosphatase and osteogenic pathways
  • Potential anti-inflammatory effects on joint tissue
  • May support collagen synthesis in connective tissue

Dosage

Typical range
1,000-3,500 mg daily (of extract)
Timing
Divided doses with meals
With food
Recommended with food for better absorption
Duration
Studies typically evaluated 4-12 weeks; long-term safety beyond 12 weeks not well established
Special populations
Insufficient safety data in pregnancy/lactation; avoid if hypercalcemic or have kidney disease

Forms

  • Standardized extract (40% ketosterones)· 70/100
  • Powder· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Generally well tolerated
  • Mild gastrointestinal upset reported in some studies
  • Headache (rare)

Contraindications

  • Hypercalcemia or parathyroid disorders
  • Severe kidney disease
  • Pregnancy and lactation (insufficient safety data)
  • History of kidney stones (theoretical risk)

Evidence notes

Limited human clinical trial data; most evidence comes from animal studies and a small number of human studies with modest sample sizes. Some positive findings for bone metabolism markers and fracture healing, but larger, well-controlled RCTs are needed. Standardization to ketosterones is appropriate but research is not extensive.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.