Performance
Phosphatidic Acid
Also known as: Mediator, Mediator PA, PA, Phosphatidic Acid (PA)
Signaling lipid that activates mTOR. May enhance muscle protein synthesis response.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Muscle building
- mTOR activation
- Strength gains
How it works
- Activates mTOR pathway
- Enhances response to training
- Cell signaling lipid
Dosage
- Typical range
- 750mg
- Timing
- Pre-workout or with meals
- With food
- Yes, with fat
- Duration
- 8+ weeks for effects
- Special populations
- Muscle building focus
Forms
- Capsule
Safety
Common side effects
- GI upset
Contraindications
- Soy allergy (check source)
Evidence notes
Emerging research for muscle building
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Performance
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.