Mineral
Manganese (as Fermented Manganese Bisglycinate)
Also known as: manganese bisglycinate, fermented manganese, chelated manganese
Manganese is an essential trace mineral involved in bone development, metabolism, and antioxidant defenses. The bisglycinate form provides optimal absorption with minimal GI side effects.
Primary uses
- Bone mineralization and skeletal development
- Antioxidant defense (manganese SOD)
- Carbohydrate and amino acid metabolism
- Fetal growth and development
How it works
- Cofactor for manganese superoxide dismutase (MnSOD)
- Required for bone matrix synthesis
- Involved in proteoglycan synthesis
- Supports aromatase and other metalloenzymes
Dosage
- Typical range
- 2 mg daily (RDA for pregnant women)
- Timing
- with meals preferred
- With food
- take with food to enhance absorption
- Duration
- throughout pregnancy and lactation
- Special populations
- Pregnant women 2 mg/day; lactating women 2.6 mg/day; do not exceed 11 mg/day
Forms
- manganese bisglycinate· 70/100
- manganese citrate· 70/100
Safety
Evidence notes
Established role in fetal skeletal development; less extensive RCT data compared to iron or zinc; deficiency is rare in prenatal populations; safety and efficacy at recommended doses well-documented.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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