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Mineral

GTF Chromium (as Fermented Chromium Glycinate, Nicotinate, Glutamate)

Also known as: GTF chromium, glucose tolerance factor chromium, chromium polynicotinate, fermented chromium

C
Evidence

GTF (Glucose Tolerance Factor) chromium is a bioactive form of chromium that supports glucose metabolism and insulin sensitivity. The fermented delivery system with glycinate and nicotinate ligands is designed to enhance absorption and biological activity.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

35 mcg / day

GTF Chromium (as Fermented Chromium Glycinate, Nicotinate, Glutamate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

  • Glucose metabolism support
  • Carbohydrate utilization
  • Insulin sensitivity
  • Blood sugar stability

How it works

  • Enhances insulin receptor signaling
  • Potentiates insulin action on muscle and adipose tissue
  • Supports glucose transporter activity
  • Cofactor for glucose tolerance factor complex

Dosage

Typical range
200 mcg daily (Adequate Intake for adults; no specific RDA for pregnancy)
Timing
with meals preferred
With food
take with food to enhance absorption
Duration
throughout pregnancy if indicated for glucose support
Special populations
Pregnant women 200 mcg/day (based on AI); do not exceed 200 mcg/day in pregnancy due to limited data

Forms

  • GTF chromium· 70/100
  • chromium polynicotinate· 70/100
  • chromium picolinate· 70/100

Safety

Contraindications

  • Diabetes (requires medical supervision if adding beyond prenatal multivitamin)

Evidence notes

Moderate evidence for chromium in glucose metabolism; GTF form is theoretically more bioavailable than inorganic chromium salts, but direct RCT evidence is limited; fermented delivery method is proprietary with preliminary data; safe at typical prenatal doses.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.