Fatty Acid
Fish Oil (EPA/DHA)
Also known as: epa, EPA, Omega-3, Pro-Resolving Mediators
Marine omega-3s with cardiovascular, brain, and anti-inflammatory benefits. EPA and DHA are the bioactive forms.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Daily target & upper limit
500 mg / dayFish Oil (EPA/DHA) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Fish Oil (EPA/DHA) dosage reference →Primary uses
- Heart health
- Brain function
- Inflammation
- Triglycerides
How it works
- EPA reduces inflammation
- DHA structural component of brain
- Lowers triglycerides
Dosage
- Typical range
- 1000-3000 mg EPA+DHA daily
- Timing
- With fat-containing meal
- With food
- Yes
- Duration
- Benefits develop over weeks
- Special populations
- Higher for triglycerides
Forms
- Triglyceride form
- Ethyl ester
- Liquid
Safety
Common side effects
- Fishy burps
- GI upset
Contraindications
- Fish allergy
- Before surgery
Products containing Fish Oil (EPA/DHA)
Top-scoring supplements in our catalog that list Fish Oil (EPA/DHA) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Extensive cardiovascular and anti-inflammatory research
Grade A: Multiple well-designed human trials support the main claims.
Cited research for Fish Oil (EPA/DHA)
Clinical studies referenced across Formulate guides that mention fish oil (epa/dha). Each links to the full study page with PubMed source + the guides that cite it.
- Nicholls et al. (2020)JAMA
Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events (STRENGTH)
- Skulas-Ray et al. (2019)Circulation
Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association
- Bhatt DL, Steg PG, Miller M, et al. (2019)New England Journal of Medicine
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT)
- Liao et al. (2019)Translational Psychiatry
Efficacy of omega-3 PUFAs in depression: a meta-analysis
- Aung et al. (2018)JAMA Cardiology
Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77,917 individuals
- Mori (2014)Fitoterapia
Omega-3 fatty acids and hypertension in humans
Fish Oil (EPA/DHA) compared head-to-head
Related in Fatty Acid
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.