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Ranked by evidence

Best Metabolism Supplements

The 10 highest-scoring metabolism supplements in Formulate's catalog, ranked by the same automated rubric we apply to every product: ingredient dose, bioavailable form, label transparency, safety, and third-party testing. No sponsorships, no pay-to-play.

Scored by the Formulate Research Team · Last reviewed July 2026

  1. 1
    Thorne
    Berberine

    A powerful botanical for heart health, metabolic support, glucose balance, and GI support* Berberine provides nutritional support for maintaining healthy cholesterol and blood s…

    96A
  2. 2
    Thorne
    Red Yeast Rice

    Helps maintain healthy cholesterol levels and supports cardiovascular health* Red Yeast Rice contains naturally occurring compounds, like phytosterols and isoflavones, produced…

    92A
  3. 3
    Transparent Labs
    Fat Burner

    This Recomp Fat Burner supports metabolism, energy, and appetite control with Green Tea, Forslean®, Capsimax®, and caffeine. Designed to aid fat loss and body composition.

    92A
  4. 4
    Pure Encapsulations
    7-KETO DHEA 50 mg

    Strongest on transparency (100/100).

    91A
  5. 5
    Pure Encapsulations
    7-KETO DHEA 100 mg

    Strongest on transparency (100/100).

    91A
  6. 6
    Pure Encapsulations
    7-KETO DHEA 25 mg

    Strongest on transparency (100/100).

    91A
  7. 7
    Double Wood
    Saffron Extract Supplement

    Strongest on transparency (100/100).

    90A
  8. 8
    Pure Encapsulations
    Biotin 8 mg

    Strongest on transparency (100/100).

    87A
  9. 9
    Nutricost
    Cayenne Pepper Capsules

    530mg Of Cayenne Pepper Per Capsule 240 Servings Per Bottle, 40,000 Heat Units 1 Bottle Can Last 8 Months Non-GMO, Gluten Free, 3rd Party Tested Made in a GMP Compliant Facility

    86A-
  10. 10
    Pure Encapsulations
    Metabolic Xtra

    Strongest on transparency (100/100).

    85A-

Frequently asked questions

What is the best metabolism supplement?

Thorne Berberine is Formulate's highest-scoring metabolism supplement at 96/100 (grade A). A powerful botanical for heart health, metabolic support, glucose balance, and GI support* Berberine provides nutritional support for maintaining healthy cholesterol and blood s…

How does Formulate rank metabolism supplements?

Each product is scored 0–100 by the same automated rubric. Clinical evidence, dose accuracy and bioavailable form carry the score; manufacturing, label transparency and safety are checked separately and can only cost points. Rankings reflect the formula on the label — not advertising or sponsorships.

How many metabolism supplements were compared?

This ranking shows the top 10 metabolism products Formulate has scored. Browse the full catalog for every product and its breakdown.

Best supplements by category

Best MineralsBest NootropicsBest AdaptogensBest Amino AcidsBest AntioxidantsBest MultivitaminsBest Heart HealthBest Energy

How these are ranked

Every metabolism product is scored on dose accuracy, ingredient form, certifications, transparency, and third-party testing — the same rubric across the whole catalog. See the methodology page for the full breakdown, or browse every supplement.

Educational only. Rankings reflect product formulation quality, not personalized medical advice. Talk to a qualified healthcare provider before starting a new supplement, especially if you take medication.