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Herbal Extract

Wolfiporia extensa Extract (Sclerotium)

Also known as: Poria cocos extract, Poria mushroom extract, Poria sclerotium, Fu Ling

C
Evidence

Wolfiporia extensa (formerly Poria cocos) is a fungal sclerotium used in traditional Chinese medicine with preliminary evidence for anxiolytic and cognitive support properties. Limited human clinical trials exist; most evidence derives from in vitro and animal studies.

Primary uses

  • Cognitive support
  • Anxiety management
  • Sleep quality
  • Stress reduction
  • General wellness

How it works

  • GABAergic activity (animal studies)
  • Modulation of neurotransmitters
  • Potential adenosine receptor interaction
  • Antioxidant effects

Dosage

Typical range
500–3000 mg daily (extract; standardization varies)
Timing
With meals; divided doses commonly used
With food
May be taken with or without food; with food may reduce GI upset
Duration
Traditional use supports long-term consumption; optimal duration for cognitive effects unclear
Special populations
Pregnant/nursing women should consult healthcare provider; safety in children not established

Forms

  • Capsule· 70/100
  • Powder· 70/100
  • Extract· 70/100

Safety

Common side effects

  • Mild GI upset
  • Allergic reactions (rare)
  • Drowsiness

Contraindications

  • Pregnancy (limited safety data)
  • Hypersensitivity to fungi
  • Concurrent immunosuppressive therapy (theoretical concern)

Evidence notes

Traditional use and preliminary in vitro/animal data support cognitive and anxiolytic claims, but human RCT evidence is limited and inconsistent. Grade C reflects moderate/preliminary evidence status without robust clinical validation.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.