Herbal Extract
Wolfiporia extensa Extract (Sclerotium)
Also known as: Poria cocos extract, Poria mushroom extract, Poria sclerotium, Fu Ling
Wolfiporia extensa (formerly Poria cocos) is a fungal sclerotium used in traditional Chinese medicine with preliminary evidence for anxiolytic and cognitive support properties. Limited human clinical trials exist; most evidence derives from in vitro and animal studies.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Cognitive support
- Anxiety management
- Sleep quality
- Stress reduction
- General wellness
How it works
- GABAergic activity (animal studies)
- Modulation of neurotransmitters
- Potential adenosine receptor interaction
- Antioxidant effects
Dosage
- Typical range
- 500–3000 mg daily (extract; standardization varies)
- Timing
- With meals; divided doses commonly used
- With food
- May be taken with or without food; with food may reduce GI upset
- Duration
- Traditional use supports long-term consumption; optimal duration for cognitive effects unclear
- Special populations
- Pregnant/nursing women should consult healthcare provider; safety in children not established
Forms
- Capsule· 70/100
- Powder· 70/100
- Extract· 70/100
Safety
Common side effects
- Mild GI upset
- Allergic reactions (rare)
- Drowsiness
Contraindications
- Pregnancy (limited safety data)
- Hypersensitivity to fungi
- Concurrent immunosuppressive therapy (theoretical concern)
Evidence notes
Traditional use and preliminary in vitro/animal data support cognitive and anxiolytic claims, but human RCT evidence is limited and inconsistent. Grade C reflects moderate/preliminary evidence status without robust clinical validation.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.