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Herbal Extract

Lion's Mane Mushroom Extract (Hericium erinaceus)

Also known as: Hericium erinaceus, Lion's Mane, Yamabushitake, Bearded Tooth Fungus

C
Evidence

Lion's Mane is a medicinal mushroom containing bioactive compounds (hericenones and erinacines) that may support cognitive function and nerve growth factor (NGF) production. Research shows promise for neurological support, though most human studies are preliminary or limited in scope.

Primary uses

  • Cognitive function and memory
  • Nerve growth factor (NGF) support
  • Neurological health
  • Mood support

How it works

  • Stimulation of nerve growth factor (NGF) production
  • Bioactive compounds (hericenones and erinacines) may cross blood-brain barrier
  • Potential neuroprotective and anti-inflammatory effects
  • Support for neuroplasticity

Dosage

Typical range
500-3000 mg daily (whole extract), typically 300-1000 mg for standardized extracts
Timing
With meals for better absorption
With food
Recommended; fat-soluble compounds may have improved bioavailability with food
Duration
Studies suggest 4-12 weeks may be needed to assess cognitive effects; long-term safety data limited
Special populations
Minimal safety data in pregnant/nursing women or children; use cautiously in individuals with mushroom allergies or immunocompromised conditions

Forms

  • Fruit body extract (powder)· 70/100
  • Fruit body extract (capsule)· 70/100
  • Standardized extract· 70/100

Safety

Common side effects

  • Gastrointestinal upset (rare)
  • Allergic reactions in sensitive individuals
  • Skin itching or numbness (anecdotal)

Contraindications

  • Known mushroom allergies or mold sensitivities
  • Concurrent immunosuppressant therapy (theoretical concern due to immune-modulating properties)
  • Pregnancy and lactation (insufficient safety data)

Evidence notes

Multiple animal and in vitro studies demonstrate NGF stimulation and neuroprotective effects. Human clinical trials are limited, small-scale, and show mixed results. Most published human evidence is from Asia with limited replication in Western populations. Fruit body extracts have more research than mycelium forms, but overall evidence remains preliminary.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.