Nootropic
Uridine Monophosphate Disodium Salt
Also known as: UMP disodium, Disodium uridine monophosphate, Uridine 5'-monophosphate disodium salt, UMP-Na2
Uridine monophosphate disodium is a nucleotide precursor form of uridine designed for enhanced bioavailability and absorption. It serves as a substrate for RNA synthesis and may support cognitive function through phosphatidylcholine production.
Primary uses
- Cognitive support
- Brain health
- Nucleotide synthesis
- Membrane phospholipid support
How it works
- Nucleotide precursor for RNA synthesis
- Substrate for phosphatidylcholine synthesis via the Kennedy pathway
- Potential support for neuronal membrane integrity and synaptic function
Dosage
- Typical range
- 250-500 mg daily
- Timing
- Can be taken anytime; often with meals for optimal absorption
- With food
- May enhance absorption when taken with food containing fats
- Duration
- Typical supplementation is ongoing; no standard duration limits established
- Special populations
- Safety in pregnancy, lactation, and pediatric populations not well characterized
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Generally well-tolerated at supplemental doses
- Rare: mild gastrointestinal upset
Contraindications
- Individuals with gout or elevated uric acid should consult a healthcare provider, as nucleotides may increase purine metabolism
Evidence notes
Uridine has preliminary evidence for cognitive support and brain health, primarily from animal and in vitro studies. Human clinical evidence remains limited. The disodium salt form is a bioavailability enhancement strategy but lacks dedicated human efficacy trials.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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