Nootropic
Uridine Monophosphate Disodium Salt
Also known as: UMP disodium, Disodium uridine monophosphate, Uridine 5'-monophosphate disodium salt, UMP-Na2
Uridine monophosphate disodium is a nucleotide precursor form of uridine designed for enhanced bioavailability and absorption. It serves as a substrate for RNA synthesis and may support cognitive function through phosphatidylcholine production.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Common questions
How much Uridine Monophosphate Disodium Salt should I take?
The typical range is 250-500 mg daily. Typical supplementation is ongoing; no standard duration limits established
When should I take Uridine Monophosphate Disodium Salt?
Can be taken anytime; often with meals for optimal absorption. May enhance absorption when taken with food containing fats.
Which form of Uridine Monophosphate Disodium Salt is best?
Capsule. Other forms in the catalog: Powder.
Is Uridine Monophosphate Disodium Salt safe?
Commonly reported: Generally well-tolerated at supplemental doses, Rare: mild gastrointestinal upset.
Which Uridine Monophosphate Disodium Salt supplement scores highest?
Double Wood Uridine Supplement, at 74/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cognitive support
- Brain health
- Nucleotide synthesis
- Membrane phospholipid support
How it works
- Nucleotide precursor for RNA synthesis
- Substrate for phosphatidylcholine synthesis via the Kennedy pathway
- Potential support for neuronal membrane integrity and synaptic function
Dosage
- Typical range
- 250-500 mg daily
- Timing
- Can be taken anytime; often with meals for optimal absorption
- With food
- May enhance absorption when taken with food containing fats
- Duration
- Typical supplementation is ongoing; no standard duration limits established
- Special populations
- Safety in pregnancy, lactation, and pediatric populations not well characterized
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Generally well-tolerated at supplemental doses
- Rare: mild gastrointestinal upset
Contraindications
- Individuals with gout or elevated uric acid should consult a healthcare provider, as nucleotides may increase purine metabolism
Products containing Uridine Monophosphate Disodium Salt
Top-scoring supplements in our catalog that list Uridine Monophosphate Disodium Salt on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Uridine has preliminary evidence for cognitive support and brain health, primarily from animal and in vitro studies. Human clinical evidence remains limited. The disodium salt form is a bioavailability enhancement strategy but lacks dedicated human efficacy trials.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.