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Nootropic

Uridine Monophosphate Disodium Salt

Also known as: UMP disodium, Disodium uridine monophosphate, Uridine 5'-monophosphate disodium salt, UMP-Na2

C
Evidence

Uridine monophosphate disodium is a nucleotide precursor form of uridine designed for enhanced bioavailability and absorption. It serves as a substrate for RNA synthesis and may support cognitive function through phosphatidylcholine production.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Cognitive support
  • Brain health
  • Nucleotide synthesis
  • Membrane phospholipid support

How it works

  • Nucleotide precursor for RNA synthesis
  • Substrate for phosphatidylcholine synthesis via the Kennedy pathway
  • Potential support for neuronal membrane integrity and synaptic function

Dosage

Typical range
250-500 mg daily
Timing
Can be taken anytime; often with meals for optimal absorption
With food
May enhance absorption when taken with food containing fats
Duration
Typical supplementation is ongoing; no standard duration limits established
Special populations
Safety in pregnancy, lactation, and pediatric populations not well characterized

Forms

  • Capsule· 70/100
  • Powder· 70/100

Safety

Common side effects

  • Generally well-tolerated at supplemental doses
  • Rare: mild gastrointestinal upset

Contraindications

  • Individuals with gout or elevated uric acid should consult a healthcare provider, as nucleotides may increase purine metabolism

Evidence notes

Uridine has preliminary evidence for cognitive support and brain health, primarily from animal and in vitro studies. Human clinical evidence remains limited. The disodium salt form is a bioavailability enhancement strategy but lacks dedicated human efficacy trials.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.