Nootropic
7,8-Dihydroxyflavone
Also known as: 7,8-DHF, dihydroxyflavone
7,8-DHF is a natural flavonoid being investigated as a potential brain-derived neurotrophic factor (BDNF) modulator with early-stage evidence in animal models. Human clinical evidence remains extremely limited, with efficacy and safety in people not yet established.
Primary uses
- Cognitive function support
- Neuroprotection
- Memory enhancement
How it works
- Proposed BDNF (brain-derived neurotrophic factor) agonist
- TrkB receptor activation in preclinical models
- Potential antioxidant activity
Dosage
- Typical range
- 25–100 mg daily (typical supplement range; optimal human dose unknown)
- Timing
- With or without food; timing studies unavailable
- With food
- No established preference; fat may improve absorption but not clinically validated
- Duration
- Long-term safety in humans unknown; most user experience anecdotal
- Special populations
- Use not studied in pregnant, nursing, pediatric, or elderly populations; caution advised
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Insufficient human data; tolerability unknown
Contraindications
- Pregnancy and nursing (inadequate safety data)
- Use with caution in those on neurologically active medications
Evidence notes
Evidence is primarily preclinical (in vitro and animal studies). No published randomized controlled trials in humans confirm efficacy or optimal dosing. Extremely limited human data; safety and bioavailability in people remain uncharacterized.
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
Related in Nootropic
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerMedical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.