Nootropic
7,8-Dihydroxyflavone
Also known as: 7,8-DHF, dihydroxyflavone
7,8-DHF is a natural flavonoid being investigated as a potential brain-derived neurotrophic factor (BDNF) modulator with early-stage evidence in animal models. Human clinical evidence remains extremely limited, with efficacy and safety in people not yet established.
Primary uses
- Cognitive function support
- Neuroprotection
- Memory enhancement
How it works
- Proposed BDNF (brain-derived neurotrophic factor) agonist
- TrkB receptor activation in preclinical models
- Potential antioxidant activity
Dosage
- Typical range
- 25–100 mg daily (typical supplement range; optimal human dose unknown)
- Timing
- With or without food; timing studies unavailable
- With food
- No established preference; fat may improve absorption but not clinically validated
- Duration
- Long-term safety in humans unknown; most user experience anecdotal
- Special populations
- Use not studied in pregnant, nursing, pediatric, or elderly populations; caution advised
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Insufficient human data; tolerability unknown
Contraindications
- Pregnancy and nursing (inadequate safety data)
- Use with caution in those on neurologically active medications
Products containing 7,8-Dihydroxyflavone
Top-scoring supplements in our catalog that list 7,8-Dihydroxyflavone on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Evidence is primarily preclinical (in vitro and animal studies). No published randomized controlled trials in humans confirm efficacy or optimal dosing. Extremely limited human data; safety and bioavailability in people remain uncharacterized.
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
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