Nootropic
7,8-Dihydroxyflavone
Also known as: 7,8-DHF, dihydroxyflavone
7,8-DHF is a natural flavonoid being investigated as a potential brain-derived neurotrophic factor (BDNF) modulator with early-stage evidence in animal models. Human clinical evidence remains extremely limited, with efficacy and safety in people not yet established.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every 7,8-Dihydroxyflavone product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nootropics Depot 4’-DMA-7,8-DHF Capsules | 79 B+ | $1.00 |
| 2 | Nootropics Depot 7,8 DHF Powder | 78 B+ | — |
| 3 | Nootropics Depot 7,8-DHF Capsules | 78 B+ | $0.50 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much 7,8-Dihydroxyflavone should I take?
The typical range is 25–100 mg daily (typical supplement range; optimal human dose unknown). Long-term safety in humans unknown; most user experience anecdotal
When should I take 7,8-Dihydroxyflavone?
With or without food; timing studies unavailable. No established preference; fat may improve absorption but not clinically validated.
Which form of 7,8-Dihydroxyflavone is best?
Capsule. Other forms in the catalog: Powder.
Is 7,8-Dihydroxyflavone safe?
Commonly reported: Insufficient human data; tolerability unknown.
Which 7,8-Dihydroxyflavone supplement scores highest?
Nootropics Depot 4’-DMA-7,8-DHF Capsules, at 79/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cognitive function support
- Neuroprotection
- Memory enhancement
How it works
- Proposed BDNF (brain-derived neurotrophic factor) agonist
- TrkB receptor activation in preclinical models
- Potential antioxidant activity
Dosage
- Typical range
- 25–100 mg daily (typical supplement range; optimal human dose unknown)
- Timing
- With or without food; timing studies unavailable
- With food
- No established preference; fat may improve absorption but not clinically validated
- Duration
- Long-term safety in humans unknown; most user experience anecdotal
- Special populations
- Use not studied in pregnant, nursing, pediatric, or elderly populations; caution advised
Forms
- Capsule· 70/100
- Powder· 70/100
Safety
Common side effects
- Insufficient human data; tolerability unknown
Contraindications
- Pregnancy and nursing (inadequate safety data)
- Use with caution in those on neurologically active medications
Products containing 7,8-Dihydroxyflavone
Top-scoring supplements in our catalog that list 7,8-Dihydroxyflavone on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Evidence is primarily preclinical (in vitro and animal studies). No published randomized controlled trials in humans confirm efficacy or optimal dosing. Extremely limited human data; safety and bioavailability in people remain uncharacterized.
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.