Nootropic
4'-Dimethylamino-7,8-dihydroxyflavone
Also known as: 4'-DMA-7,8-DHF, Eutropoflavin, 7,8-dihydroxyflavone derivative, DMA-DHF
4'-DMA-7,8-DHF is a synthetic flavone derivative designed as a brain-derived neurotrophic factor (BDNF) mimetic for cognitive support. Evidence is extremely preliminary, with only limited in vitro and early-stage animal research; human efficacy and safety data are not yet established.
Primary uses
- Cognitive enhancement
- BDNF modulation
- Neuroprotection (theoretical)
How it works
- Potential BDNF TrkB receptor agonist
- Purported to cross blood-brain barrier
- May support neuroplasticity signaling pathways
Dosage
- Typical range
- 50-150 mg daily (based on supplement label recommendations; not clinically validated)
- Timing
- Morning, typically with food
- With food
- Likely beneficial due to hydrophobic nature, but not formally studied
- Duration
- Optimal duration unknown; long-term safety not established
- Special populations
- Pregnant/nursing women and children should avoid due to lack of safety data
Forms
- Capsule· 70/100
Safety
Common side effects
- Unknown in humans; not formally studied
Contraindications
- Pregnancy and lactation (precautionary)
- No human safety data available
Evidence notes
No published human clinical trials located. Mechanism is based on structural analogy to 7,8-dihydroxyflavone and in vitro modeling. Real-world efficacy, bioavailability, and safety in humans remain completely unvalidated.
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
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