Nootropic
NSI-189 (Informational)
Also known as: NSI-189
Experimental neurogenic compound being studied for depression. Not approved for use.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Neurogenesis
- Depression research
- Hippocampal growth
How it works
- Stimulates hippocampal neurogenesis
- Novel mechanism
- Depression clinical trials
Dosage
- Typical range
- Clinical trials: 40-80 mg
- Timing
- N/A for public
- With food
- N/A
- Duration
- Not approved
- Special populations
- Clinical trial participants only
Forms
- Research material
Safety
Common side effects
- Unknown at large scale
Contraindications
- Not for public use
Evidence notes
Experimental - not for general use
Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.
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