Joint Health
UC-II (Undenatured Type II Collagen)
Also known as: Undenatured collagen, Native collagen type II
Specialized collagen that works through immune modulation rather than building blocks. Low dose, high effect.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every UC-II (Undenatured Type II Collagen) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations Joint Complex (single dose) | 81 A- | $2.03 |
| 2 | Kirkland Signature Triple Action Joint Health, 110 Coated Tablets | 79 B+ | $0.26 |
| 3 | Doctor's Best Glucosamine Chondroitin, MSM + UCII, 90 Veggie Capsule | 72 B | $0.77 |
| 4 | Healthy Origins UC-II | 72 B | $0.33 |
| 5 | Codeage Supreme Joint Health | 69 B | $1.67 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much UC-II (Undenatured Type II Collagen) should I take?
The typical range is 40mg daily. 90+ days for effect
When should I take UC-II (Undenatured Type II Collagen)?
Away from food (empty stomach). No (before bed ideal).
Which form of UC-II (Undenatured Type II Collagen) is best?
UC-II capsules — Specific patented form.
Is UC-II (Undenatured Type II Collagen) safe?
Commonly reported: Rare GI upset. Serious warnings: None. Safe
Which UC-II (Undenatured Type II Collagen) supplement scores highest?
Pure Encapsulations Joint Complex (single dose), at 81/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Joint health
- Immune modulation
- Cartilage
- OA
How it works
- Oral tolerance induction
- Immune system modulation
- Different from hydrolyzed collagen
Dosage
- Typical range
- 40mg daily
- Timing
- Away from food (empty stomach)
- With food
- No (before bed ideal)
- Duration
- 90+ days for effect
- Special populations
- OA, joint support
Forms
- UC-II capsules
Safety
Common side effects
- Rare GI upset
Contraindications
- None
Products containing UC-II (Undenatured Type II Collagen)
Top-scoring supplements in our catalog that list UC-II (Undenatured Type II Collagen) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Unique mechanism, good evidence
Grade A: Multiple well-designed human trials support the main claims.
Related in Joint Health
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.