Joint Health
UC-II (Undenatured Type II Collagen)
Also known as: Undenatured collagen, Native collagen type II
A
Evidence
Specialized collagen that works through immune modulation rather than building blocks. Low dose, high effect.
Primary uses
- Joint health
- Immune modulation
- Cartilage
- OA
How it works
- Oral tolerance induction
- Immune system modulation
- Different from hydrolyzed collagen
Dosage
- Typical range
- 40mg daily
- Timing
- Away from food (empty stomach)
- With food
- No (before bed ideal)
- Duration
- 90+ days for effect
- Special populations
- OA, joint support
Forms
- UC-II capsules
Safety
Common side effects
- Rare GI upset
Contraindications
- None
Evidence notes
Unique mechanism, good evidence
Grade A: Multiple well-designed human trials support the main claims.
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