Joint Health
UC-II (Undenatured Type II Collagen)
Also known as: Undenatured collagen, Native collagen type II
Specialized collagen that works through immune modulation rather than building blocks. Low dose, high effect.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Joint health
- Immune modulation
- Cartilage
- OA
How it works
- Oral tolerance induction
- Immune system modulation
- Different from hydrolyzed collagen
Dosage
- Typical range
- 40mg daily
- Timing
- Away from food (empty stomach)
- With food
- No (before bed ideal)
- Duration
- 90+ days for effect
- Special populations
- OA, joint support
Forms
- UC-II capsules
Safety
Common side effects
- Rare GI upset
Contraindications
- None
Evidence notes
Unique mechanism, good evidence
Grade A: Multiple well-designed human trials support the main claims.
Related in Joint Health
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.