Herbal Extract
Rephyll (Piper nigrum) Extract with Beta-Caryophyllene
Also known as: Beta-caryophyllene extract, BCP, Black pepper fruit extract, Piper nigrum extract
Rephyll is a standardized black pepper (Piper nigrum) fruit extract concentrated for beta-caryophyllene (BCP), a sesquiterpene with preliminary evidence for anti-inflammatory and neuroprotective effects. Most human data remains limited, with the majority of research conducted in vitro or in animal models.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Anti-inflammatory support
- Neuroprotection
- Joint comfort
- Stress response modulation
How it works
- CB2 cannabinoid receptor agonism (proposed)
- Anti-inflammatory cytokine modulation
- Oxidative stress reduction
- Neuroprotective signaling pathway activation
Dosage
- Typical range
- 100-200 mg daily (based on 6-10% BCP concentration; equivalent to ~6-20 mg BCP)
- Timing
- With meals for optimal absorption
- With food
- Recommended; fat-soluble compound benefits from dietary fat
- Duration
- No established maximum duration; most preliminary studies use 4-12 week periods
- Special populations
- Pregnancy/nursing: insufficient data; those on anticoagulants should consult healthcare provider
Forms
- Powder· 70/100
- Capsule· 70/100
- Liquid extract· 70/100
Safety
Common side effects
- Generally well-tolerated at typical doses
- Rare: mild gastrointestinal upset
Contraindications
- Anticoagulant/antiplatelet medications (theoretical bleeding risk; limited evidence)
- Allergy to Piper nigrum or related plants
Products containing Rephyll (Piper nigrum) Extract with Beta-Caryophyllene
Top-scoring supplements in our catalog that list Rephyll (Piper nigrum) Extract with Beta-Caryophyllene on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Limited human clinical trial data; most evidence is preclinical (in vitro/animal). Beta-caryophyllene shows mechanistic promise but lacks robust RCT confirmation in humans. Rephyll as a branded extract is under-studied relative to component BCP.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.