Skip to main content

Herbal Extract

Rephyll (Piper nigrum) Extract with Beta-Caryophyllene

Also known as: Beta-caryophyllene extract, BCP, Black pepper fruit extract, Piper nigrum extract

C
Evidence

Rephyll is a standardized black pepper (Piper nigrum) fruit extract concentrated for beta-caryophyllene (BCP), a sesquiterpene with preliminary evidence for anti-inflammatory and neuroprotective effects. Most human data remains limited, with the majority of research conducted in vitro or in animal models.

Primary uses

  • Anti-inflammatory support
  • Neuroprotection
  • Joint comfort
  • Stress response modulation

How it works

  • CB2 cannabinoid receptor agonism (proposed)
  • Anti-inflammatory cytokine modulation
  • Oxidative stress reduction
  • Neuroprotective signaling pathway activation

Dosage

Typical range
100-200 mg daily (based on 6-10% BCP concentration; equivalent to ~6-20 mg BCP)
Timing
With meals for optimal absorption
With food
Recommended; fat-soluble compound benefits from dietary fat
Duration
No established maximum duration; most preliminary studies use 4-12 week periods
Special populations
Pregnancy/nursing: insufficient data; those on anticoagulants should consult healthcare provider

Forms

  • Powder· 70/100
  • Capsule· 70/100
  • Liquid extract· 70/100

Safety

Common side effects

  • Generally well-tolerated at typical doses
  • Rare: mild gastrointestinal upset

Contraindications

  • Anticoagulant/antiplatelet medications (theoretical bleeding risk; limited evidence)
  • Allergy to Piper nigrum or related plants

Evidence notes

Limited human clinical trial data; most evidence is preclinical (in vitro/animal). Beta-caryophyllene shows mechanistic promise but lacks robust RCT confirmation in humans. Rephyll as a branded extract is under-studied relative to component BCP.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Herbal Extract

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.